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首页> 外文期刊>Acta biomaterialia >Fluorescent mesoporous silica nanotubes incorporating CdS quantum dots for controlled release of ibuprofen.
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Fluorescent mesoporous silica nanotubes incorporating CdS quantum dots for controlled release of ibuprofen.

机译：包含CdS量子点的荧光中孔二氧化硅纳米管，用于控制布洛芬的释放。

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摘要

Mesoporous silica nanotubes (MSNTs) and amine-functionalized MSNTs (NH(2)-MSNTs) have been successfully synthesized via a sol-gel route using needle-like CaCO(3) nanoparticles as inorganic templates and post-modification with 3-aminopropyltriethoxysilane. Subsequently, the preformed nanotubes were functionalized with blue fluorescent CdS quantum dots, as demonstrated by transmission electron microscopy and confocal laser scanning microscopy. The morphology and microstructure of the produced materials were characterized by scanning electron microscopy and N(2) adsorption-desorption measurements. A comparative study of the capacity of several kinds of nanotube materials to store ibuprofen indicated that the drug-loading amount in CdS-NH(2)-MSNTs (CdS-incorporated NH(2)-MSNTs) could reach up to 740 mg/g silica, similar to that in as-prepared MSNTs (762 mg/g silica) and NH(2)-MSNTs (775 mg/g silica). Drug release studies in simulated body fluid revealed that the loaded ibuprofen released from amine-functionalized systems at a significantly lower release rate as compared to that from amine-free systems, and the incorporation of CdS quantum dots had nearly no effect on the ibuprofen release process. Further study on the ibuprofen release from CdS-NH(2)-MSNTs in other media, i.e. borate buffer saline, pure water and normal saline, indicated that CdS-NH(2)-MSNTs are pH- and ion-sensitive drug carriers, which should facilitate controlled drug delivery and disease therapy.
机译：介孔二氧化硅纳米管（MSNTs）和胺官能化MSNTs（NH（2）-MSNTs）已通过使用针状CaCO（3）纳米粒子作为无机模板通过溶胶-凝胶途径成功合成，并用3-氨丙基三乙氧基硅烷进行了后修饰。随后，将预制的纳米管用蓝色荧光CdS量子点进行功能化，如透射电子显微镜和共聚焦激光扫描显微镜所示。通过扫描电子显微镜和N（2）吸附-脱附测量来表征所生产材料的形态和微观结构。对几种纳米管材料存储布洛芬容量的比较研究表明，CdS-NH（2）-MSNTs（掺有CdS的NH（2）-MSNTs）中的载药量可达到740 mg / g二氧化硅，与所制备的MSNTs（762 mg / g二氧化硅）和NH（2）-MSNTs（775 mg / g二氧化硅）相似。在模拟体液中的药物释放研究表明，负载的布洛芬从胺官能化系统释放的释放速率比无胺系统释放的释放速率低得多，并且CdS量子点的掺入对布洛芬释放过程几乎没有影响。对布洛芬从CdS-NH（2）-MSNTs在其他介质（例如硼酸盐缓冲盐水，纯水和生理盐水）中释放的进一步研究表明，CdS-NH（2）-MSNTs是pH敏感和离子敏感的药物载体，这应该有助于药物的控制和疾病治疗。

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