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首页> 外文期刊>Acta biomaterialia >Computational modelling of biomaterial surface interactions with blood platelets and osteoblastic cells for the prediction of contact osteogenesis.
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Computational modelling of biomaterial surface interactions with blood platelets and osteoblastic cells for the prediction of contact osteogenesis.

机译：用于预测接触性成骨的生物材料表面与血小板和成骨细胞相互作用的计算模型。

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摘要

Surface microroughness can induce contact osteogenesis (bone formation initiated at the implant surface) around oral implants, which may result from different mechanisms, such as blood platelet-biomaterial interactions and/or interaction with (pre-)osteoblast cells. We have developed a computational model of implant endosseous healing that takes into account these interactions. We hypothesized that the initial attachment and growth factor release from activated platelets is crucial in achieving contact osteogenesis. In order to investigate this, a computational model was applied to an animal experiment [7] that looked at the effect of surface microroughness on endosseous healing. Surface-specific model parameters were implemented based on in vitro data (Lincks et al. Biomaterials 1998;19:2219-32). The predicted spatio-temporal patterns of bone formation correlated with the histological data. It was found that contact osteogenesis could not be predicted if only the osteogenic response of cells was up-regulated by surface microroughness. This could only be achieved if platelet-biomaterial interactions were sufficiently up-regulated as well. These results confirmed our hypothesis and demonstrate the added value of the computational model to study the importance of surface-mediated events for peri-implant endosseous healing.
机译：表面微粗糙度可引起口腔植入物周围的接触成骨（在植入物表面开始的骨形成），这可能是由于不同的机制引起的，例如血小板-生物材料的相互作用和/或与（成）成骨细胞的相互作用。我们已经开发了考虑这些相互作用的植入物骨内愈合的计算模型。我们假设活化血小板的初始附着和生长因子释放对于实现接触性成骨至关重要。为了对此进行研究，将计算模型应用于动物实验[7]，该实验研究了表面微粗糙度对骨内愈合的影响。表面特异性模型参数是基于体外数据实现的（Lincks等，生物材料，1998; 19：2219-32）。预测的骨形成的时空模式与组织学数据相关。发现如果仅通过表面微粗糙度上调细胞的成骨反应，则不能预测接触成骨。这只有在血小板与生物材料之间的相互作用也被充分上调的情况下才能实现。这些结果证实了我们的假设，并证明了计算模型的附加价值，以研究表面介导的事件对种植体周围骨内愈合的重要性。

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