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首页> 外文期刊>Acta biomaterialia >Submicron-textured biomaterial surface reduces staphylococcal bacterial adhesion and biofilm formation
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Submicron-textured biomaterial surface reduces staphylococcal bacterial adhesion and biofilm formation

机译：亚微米质感的生物材料表面可减少葡萄球菌细菌粘附和生物膜形成

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摘要

Staphylococci are among the most important pathogens causing bloodstream infections associated with implanted medical devices. Control of bacterial adhesion to material surfaces is important for prevention of biofilm formation and biomaterial-associated infections. In this study, we hypothesized that submicron (staphylococcal bacterial dimension) surface textures may reduce the bacterial adhesion via a decrease in surface area that bacteria can contact, and subsequently inhibit biofilm formation. Poly(urethane urea) films were textured with two different sizes of submicron pillars via a two-stage replication process. Adhesion of two bacterial strains (Staphylococcus epidermidis RP62A and S. aureus Newman) was assessed over a shear stress range of 0-13.2 dyn cm -2 using a rotating disk system in physiological buffer solutions. Significant decreases in bacterial adhesion were observed on textured surfaces for both strains compared with smooth controls. Biofilm formation was further tested on surfaces incubated in solution for either 2 or 5 days and it was found that biofilm formation was dramatically inhibited on textured surfaces. The results of the approaches used in this work demonstrate that patterned surface texturing of biomaterials provides an effective means to reduce staphylococcal adhesion and biofilm formation on biomaterial surfaces, and thus to prevent biomaterial-associated infections.
机译：葡萄球菌是最重要的病原体之一，可导致与植入的医疗设备相关的血液感染。控制细菌粘附在材料表面上对于防止生物膜形成和生物材料相关感染很重要。在这项研究中，我们假设亚微米（葡萄球菌细菌大小）表面纹理可能会通过减少细菌可以接触的表面积而减少细菌粘附，从而抑制生物膜的形成。通过两步复制过程，用两种不同尺寸的亚微米柱对聚氨基甲酸乙酯脲膜进行织构。使用生理学缓冲溶液中的旋转盘系统，在0-13.2 dyn cm -2的剪切应力范围内评估了两种细菌菌株（表皮葡萄球菌RP62A和金黄色葡萄球菌Newman）的粘附力。与光滑对照相比，在两种菌株的织构表面上均观察到细菌粘附的显着降低。在溶液中孵育2天或5天的表面上进一步测试了生物膜的形成，发现在纹理表面上生物膜的形成受到了显着抑制。在这项工作中使用的方法的结果表明，对生物材料进行图案化的表面纹理化处理可提供减少葡萄球菌粘附和生物材料表面上生物膜形成的有效方法，从而防止与生物材料相关的感染。

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