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首页> 外文期刊>Acta biomaterialia >Biomimetic poly(lactide) based fibrous scaffolds for ligament tissue engineering.
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Biomimetic poly(lactide) based fibrous scaffolds for ligament tissue engineering.

机译：用于韧带组织工程的仿生聚丙交酯纤维支架。

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摘要

The aim of this study was to fabricate a fibrous scaffold that closely resembled the micro-structural architecture and mechanical properties of collagen fibres found in the anterior cruciate ligament (ACL). To achieve this aim, fibrous scaffolds were made by electrospinning L-lactide based polymers. L-Lactide was chosen primarily due to its demonstrated biocompatibility, biodegradability and high modulus. The electrospun fibres were collected in tension on a rotating wire mandrel. Upon treating these fibres in a heated aqueous environment, they possessed a crimp-like pattern having a wavelength and amplitude similar to that of native ACL collagen. Of the polymer fibre scaffolds studied, those made from poly(L-lactide-co-D,L-lactide) PLDLA exhibited the highest modulus and were also the most resilient to in vitro hydrolytic degradation, undergoing a slight decrease in modulus compared to the other polymeric fibres over a 6 month period. Bovine fibroblasts seeded on the wavy, crimp-like PLDLA fibres attached, proliferated and deposited extracellular matrix (ECM) molecules on the surface of the fibrous scaffold. In addition, the deposited ECM exhibited bundle formation that resembled the fascicles found in native ACL. These findings demonstrate the importance of replicating the geometric microenvironment in developing effective tissue engineering scaffolds.
机译：这项研究的目的是制造一种纤维支架，该支架与前十字韧带（ACL）中发现的胶原纤维的微观结构和机械性能极为相似。为了实现该目的，通过静电纺丝基于L-丙交酯的聚合物来制备纤维状支架。选择L-丙交酯主要是因为其具有生物相容性，生物降解性和高模量。将电纺纤维在张力下收集在旋转的线芯轴上。在加热的水环境中处理这些纤维时，它们具有卷曲样的图案，其波长和幅度与天然ACL胶原的相似。在研究的聚合物纤维支架中，由聚（L-丙交酯-co-D，L-丙交酯）PLDLA制成的支架表现出最高的模量，并且对体外水解降解也最有弹性，与模塑料相比，模量略有下降。在6个月内使用其他聚合物纤维。牛成纤维细胞接种在波浪状，卷曲状PLDLA纤维上，附着在纤维支架表面上，增殖并沉积在细胞外基质上。此外，沉积的ECM表现出类似于天然ACL中的束的束形成。这些发现证明了在开发有效的组织工程支架中复制几何微环境的重要性。

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