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首页> 外文期刊>Acta biomaterialia >Delivery of demineralized bone matrix powder using a thermogelling chitosan carrier
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Delivery of demineralized bone matrix powder using a thermogelling chitosan carrier

机译：使用热凝胶壳聚糖载体输送脱矿质的骨基质粉末

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摘要

Demineralized bone matrix (DBM) powder is widely used for bone regeneration due to its osteoinductivity and osteoconductivity. However, difficulties with handling, its tendency to migrate from graft sites, and lack of stability after surgery can sometimes limit the clinical utility of this material. In this work, the possibility of using a thermogelling chitosan carrier to deliver DBM powder was assessed. The DBM-thermogelling putty improved handling and formed a gel-like composite in situ at body temperature within a clinically relevant time period. The properties of the formed composite, including morphology, porosity, mechanical properties, equilibrium swelling as well as degradability, are significantly influenced by the ratio of DBM to thermogelling chitosan. The in vitro study showed that the alkaline phosphatase activity of C2C12 cells encapsulated in the composite was steadily increased with culture time. The in vivo study showed that increased DBM content in the DBM-thermogelling chitosan induced ectopic bone formation in a nude rat model. The diffusion of growth factor from the DBM-thermogelling chitosan as well as the host-implant interactions are discussed.
机译：脱矿质骨基质（DBM）粉末由于其骨诱导性和骨传导性而被广泛用于骨再生。但是，操作上的困难，其从移植部位迁移的趋势以及手术后缺乏稳定性有时会限制这种材料的临床应用。在这项工作中，评估了使用热凝胶化壳聚糖载体递送DBM粉末的可能性。 DBM热凝腻子改善了处理，并在临床相关时间段内在体温下原位形成了凝胶状复合材料。形成的复合材料的性能，包括形态，孔隙率，机械性能，平衡溶胀以及可降解性，受DBM与热凝胶化壳聚糖之比的影响很大。体外研究表明，包裹在复合物中的C2C12细胞的碱性磷酸酶活性随培养时间的增加而稳定增加。体内研究表明，在裸鼠模型中，DBM热凝胶化壳聚糖中DBM含量的增加诱导了异位骨的形成。讨论了DBM-热凝胶化壳聚糖中生长因子的扩散以及宿主与植物的相互作用。

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