• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Non-invasive monitoring of tissue scaffold degradation using ultrasound elasticity imaging.
【24h】

Non-invasive monitoring of tissue scaffold degradation using ultrasound elasticity imaging.

机译：使用超声弹性成像对组织支架降解进行非侵入性监测。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Non-invasively monitoring the extent of cell growth, scaffold degradation and tissue development will greatly help tissue engineers to monitor in vivo regenerate tissue function and scaffold degradation. Currently available methods for tissue and scaffold degradation analysis, such as histology and direct mechanical measurements, are not suitable for continuous monitoring of the same sample in vivo as they destroy cells, tissue matrix and scaffolds. In addition, different samples are prepared and measured at varying times, but high tissue growth deviation between specimens and the need for monitoring tissue growth and scaffold degradation at different times requires large sample numbers for statistical analysis. Ultrasound elasticity imaging (UEI) based on phase-sensitive speckle tracking can characterize the internal structural, compositional and functional change of biomaterial scaffolds and engineered tissues at high resolution. In this study, UEI resolution was 250mum (axial) by 500mum (lateral) using a commercial ultrasound transducer centered at 5MHz. This method allows characterization of both globally and locally altered scaffold and engineered tissue elastic properties. Preliminary in vitro and in vivo results with poly(1,8-octanediol-co-citrate) scaffolds support the feasibility of UEI as a non-invasive quantitative monitoring tool for scaffold degradation and engineered tissue formation. This novel non-invasive monitoring tool will provide direct, time-dependent feedback on scaffold degradation and tissue ingrowth for tissue engineers to improve the design process.
机译：非侵入性地监测细胞生长，支架降解和组织发育的程度将极大地帮助组织工程师监测体内再生的组织功能和支架降解。用于组织和支架降解分析的当前可用方法（例如组织学和直接机械测量）不适用于体内连续监测同一样品的方法，因为它们会破坏细胞，组织基质和支架。另外，在不同的时间准备和测量不同的样品，但是样品之间的高组织生长偏差以及在不同时间监视组织生长和支架降解的需求需要大量的样品用于统计分析。基于相敏斑点跟踪的超声弹性成像（UEI）可以高分辨率表征生物材料支架和工程组织的内部结构，组成和功能变化。在这项研究中，使用以5MHz为中心的商用超声换能器，UEI分辨率为250mum（轴向）乘以500mum（横向）。这种方法可以表征整体和局部改变的支架和工程组织的弹性。聚（1,8-辛二醇-柠檬酸酯-共柠檬酸盐）支架的体外和体内初步结果支持UEI作为支架降解和工程组织形成的非侵入性定量监测工具的可行性。这种新颖的非侵入性监测工具将为组织工程师提供有关支架降解和组织向内生长的直接，时间相关的反馈，以改善组织设计过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号