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首页> 外文期刊>Acta biomaterialia >Transferrin-conjugated curcumin-loaded superparamagnetic iron oxide nanoparticles induce augmented cellular uptake and apoptosis in K562 cells
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Transferrin-conjugated curcumin-loaded superparamagnetic iron oxide nanoparticles induce augmented cellular uptake and apoptosis in K562 cells

机译：运铁蛋白缀合的姜黄素负载超顺磁性氧化铁纳米颗粒诱导K562细胞细胞摄取和凋亡增加

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摘要

Superparamagnetic iron oxide nanoparticles are currently used for precise drug delivery and as an image contrast agent. In the present study, the potentiality of curcumin-loaded magnetic nanoparticles (Cur-MNPs) for the treatment of chronic myeloid leukemia (CML) was investigated. For active therapy, transferrin (Tf) ligand was further conjugated to Cur-MNPs, which demonstrated enhanced uptake compared to Cur-MNPs in p210bcr/abl-positive cell line (K562). Cur-MNPs demonstrated greater and sustained anti-proliferative activity in a dose- and time-dependent manner; however, with the advent of a magnetic field the anti-proliferative activity of Cur-MNPs as well as Tf-Cur-MNPs was enhanced due to higher cellular uptake with enhanced cytotoxicity activity. Down-regulation of Bcr-Abl protein activates intrinsic apoptotic pathways for promoting anti-leukemic responses. Our in vitro results advocate potential clinical applications of Cur-MNPs by activating multiple signaling pathways for provoking the anti-leukemic activity.
机译：超顺磁性氧化铁纳米粒子目前用于精确的药物输送和图像造影剂。在本研究中，研究了姜黄素负载的磁性纳米颗粒（Cur-MNPs）在治疗慢性粒细胞白血病（CML）中的潜力。对于主动治疗，转铁蛋白（Tf）配体进一步与Cur-MNPs结合，与p210bcr / abl阳性细胞系（K562）的Cur-MNPs相比，其摄取增强。 Cur-MNP以剂量和时间依赖性的方式表现出更大且持续的抗增殖活性。然而，随着磁场的出现，Cur-MNPs和Tf-Cur-MNPs的抗增殖活性由于更高的细胞摄取和增强的细胞毒性而得到增强。 Bcr-Abl蛋白的下调激活内在的凋亡途径，以促进抗白血病反应。我们的体外结果通过激活多种信号通路激发抗白血病活性，提倡Cur-MNPs的潜在临床应用。

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