In vitro antileishmanial activity of aza-scorpiand macrocycles. Inhibition of the antioxidant enzyme iron superoxide dismutase

Marin Clotilde; Inclan Mario; Ramirez-Macias Inmaculada; Teresa Albelda M.; Canas Rocio; Paz Clares M.; Gonzalez-Garcia Jorge; Jose Rosales Maria; Urbanova Kristina; Garcia-Espana Enrique; Sanchez-Moreno Manuel

首页> 外文期刊>RSC Advances >In vitro antileishmanial activity of aza-scorpiand macrocycles. Inhibition of the antioxidant enzyme iron superoxide dismutase

【24h】

In vitro antileishmanial activity of aza-scorpiand macrocycles. Inhibition of the antioxidant enzyme iron superoxide dismutase

机译：AZA-SCORPIAND宏γ的体外抗体活动。抑制抗氧化酶铁超氧化物歧化酶

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The in vitro leishmanicidal activity of a series of nine aza-scorpiand-like macrocycles, recently synthesized, was tested on Leishmania infantum, Leishmania braziliensis and Leishmania donovani parasites, using promastigotes and intracellular amastigotes forms. The cytotoxicity of the tested compounds on J774.2 macrophage cells was also measured. Four of the tested compounds (1, 2, 8 and 9) showed selectivity indexes higher than those of the reference drug Glucantime for the three Leishmania species. Moreover, the data on infection rates and on amastigotes showed that compounds 1, 2, 8 and 9 are the most active against the three Leishmania species. The changes in the excretion product profile of parasites treated with the four compounds (1, 2, 8 and 9) were also consistent with substantial cytoplasmic alterations. On the other hand, the most active compounds were potent inhibitors of Fe-SOD in the three parasite species considered, whereas their impact on human CuZn-SOD was low. The high activity, low toxicity, stability, low cost of the starting materials and straightforward synthesis make these compounds appropriate molecules for the development of affordable anti-leishmanicidal agents.

机译：最近合成的一系列九种Aza-scorpiand的宏杂种的体外Leishmanicatoral活性在Leishmania Infantum，Leishmania Braziliensis和Leishmania Donovani寄生虫上进行了测试，使用Promastigotes和细胞内Amastigotes形式。还测量了在J774.2巨噬细胞上的测试化合物的细胞毒性。四种测试化合物（1,2,8和9）显示了比三个LeishMania物种的参考药物葡萄糖的选择性指标高。此外，关于感染率和Amastigot的数据显示，化合物1,2,8和9对三种LeishMania物种最活跃。用四种化合物（1,2,8和9）处理的寄生虫的排泄产物谱的变化也与大量细胞质改变一致。另一方面，最活跃的化合物是在考虑的三种寄生虫物种中的Fe-SOD有效抑制剂，而它们对人Cuzn-Sod的影响很低。起始材料的高活性，低毒性，稳定性，低成本和直接合成使得这些化合物适当的分子用于显着的抗Leishmanicatoger的发育。

著录项

来源
《RSC Advances》 |2016年第21期|共10页
作者
Marin Clotilde; Inclan Mario; Ramirez-Macias Inmaculada; Teresa Albelda M.; Canas Rocio; Paz Clares M.; Gonzalez-Garcia Jorge; Jose Rosales Maria; Urbanova Kristina; Garcia-Espana Enrique; Sanchez-Moreno Manuel;
展开▼
作者单位

Univ Granada Hosp Univ Granada Inst Invest Biosanitaria Ibs GRANADA Dept Parasitol Granada Spain;

Univ Valencia Inst Ciencia Mol Dept Quim Inorgan E-46980 Paterna Valencia Spain;

Univ Granada Hosp Univ Granada Inst Invest Biosanitaria Ibs GRANADA Dept Parasitol Granada Spain;

Hosp Univ &

Politecn La Fe GIBI 230 Valencia Spain;

Univ Granada Hosp Univ Granada Inst Invest Biosanitaria Ibs GRANADA Dept Parasitol Granada Spain;

Univ Valencia Inst Ciencia Mol Dept Quim Inorgan E-46980 Paterna Valencia Spain;

Univ Valencia Inst Ciencia Mol Dept Quim Inorgan E-46980 Paterna Valencia Spain;

Univ Granada Hosp Univ Granada Inst Invest Biosanitaria Ibs GRANADA Dept Parasitol Granada Spain;

Univ Granada Hosp Univ Granada Inst Invest Biosanitaria Ibs GRANADA Dept Parasitol Granada Spain;

Univ Valencia Inst Ciencia Mol Dept Quim Inorgan E-46980 Paterna Valencia Spain;

Univ Granada Hosp Univ Granada Inst Invest Biosanitaria Ibs GRANADA Dept Parasitol Granada Spain;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. In vitro antileishmanial activity of aza-scorpiand macrocycles. Inhibition of the antioxidant enzyme iron superoxide dismutase [J] . Marin Clotilde, Inclan Mario, Ramirez-Macias Inmaculada, RSC Advances . 2016,第21期

机译：AZA-SCORPIAND宏γ的体外抗体活动。抑制抗氧化酶铁超氧化物歧化酶
2. In vitro antileishmanial activity and iron superoxide dismutase inhibition of arylamine Mannich base derivatives [J] . Martin-Montes Alvaro, Santivanez-Veliz Mery, Moreno-Viguri Elsa, Parasitology . 2017,第13期

机译：芳胺曼尼希碱衍生物的体外抗体癌症活性和铁超氧化铁歧化酶抑制作用
3. IDENTIFICATION OF IRON SUPEROXIDE DISMUTASE AND A COPPER/ZINC SUPEROXIDE DISMUTASE ENZYME ACTIVITY WITHIN THE MARINE CYANOBACTERIUM SYNECHOCOCCUS SP WH 7803 [J] . Chadd HE., Mann NH., Carr NG., FEMS Microbiology Letters . 1996,第2a3期

机译：海洋蓝藻SYNECHOCOCCUS SP WH 7803中铁超氧化物歧化酶和铜/锌超氧化物歧化酶活性的鉴定
4. The effect of NaCl stress on antioxidant enzymes activity in transgenic sweetpotato expressing CuZn superoxide dismutase and ascorbate peroxidase genes [C] . Wang Xin, Guo Xiaoming, Li Qiang, Sweetpotato in food and energy security. . 2010

机译：NaCl胁迫对转基因甘薯表达CuZn超氧化物歧化酶和抗坏血酸过氧化物酶基因抗氧化酶活性的影响。
5. Structural studies of the antioxidant defense enzymes: Copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein. [D] . Roberts, Blaine R. 2007

机译：抗氧化防御酶的结构研究：铜，锌超氧化物歧化酶和烷基氢过氧化物还原酶黄素蛋白。
6. Activities of Antioxidant Scavenger Enzymes (Superoxide Dismutase and Glutathione Peroxidase) in Erythrocytes in Adult Women With and Without Type II Diabetes [O] . Eli Carmeli, Raymond Coleman, Yitshal N. Berner 2004

机译：成年女性和不患有II型糖尿病的成年女性红细胞中抗氧化剂清除剂酶（超氧化物歧化酶和谷胱甘肽过氧化物酶）的活性
7. Identification of iron Superoxide dismutase and a copper/zinc Superoxide dismutase enzyme activity within the marine cyanobacterium Synechococcus sp. WH 7803 [O] . H Chadd 1996

机译：铁超氧化物歧化酶的鉴定及铜/锌超氧化物歧化酶活性在海洋区肌腱菌杆菌SP中。 WH 7803.
8. The Protective Roles of the Antioxidant Enzymes Superoxide Dismutase and Catalase in the Green Photosynthetic Bacterium Chloroflexus Aurantiacus [R] . Blankenship, Robert E. 2004

机译：抗氧化酶超氧化物歧化酶和过氧化氢酶在绿色光合细菌Chloroflexus aurantiacus中的保护作用

In vitro antileishmanial activity of aza-scorpiand macrocycles. Inhibition of the antioxidant enzyme iron superoxide dismutase

摘要

著录项

相似文献

相关主题

期刊订阅