• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Biodegradable, thermoresponsive PNIPAM-based hydrogel scaffolds for the sustained release of levofloxacin
【24h】

Biodegradable, thermoresponsive PNIPAM-based hydrogel scaffolds for the sustained release of levofloxacin

机译：可生物降解，热型泊普米的水凝胶支架，用于左氧氟沙星的持续释放

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A series of novel thermoresponsive biodegradable hydrogels (TBHs) was prepared from N-isopropyl acrylamide (NIPAM) and two biodegradable crosslinkers, poly(epsilon-caprolactone) dimethacrylate (PCLDMA) and bisacryloylcystamine (BACy). The morphology, thermal behavior, swelling/deswelling kinetics, compression properties, in vitro drug delivery and biodegradation were investigated. The results indicated that the properties of the TBHs strongly depended on temperature and the feeding molar ratio of the PCLDMA to BACy components. Levofloxacin (LVF)-loaded hydrogels were prepared to explore their stimuli-responsive release process. The cumulative release profile of LVF-loaded TBHs exhibited a thermo-induced slow sustained drug release and a reduction-induced fast release. At a physiological pH, TBHs could be biodegraded slowly in glutathione (GSH) at 37 degrees C. Due to their homogeneous pore diameter, highly interconnected architecture, degradable chemistry and thermoresponsive properties, the TBHs developed herein are highly attractive with respect to tissue engineering scaffold applications.
机译：由丙烯酰胺（NIPAM）和两个可生物降解的交联剂（Poly（Epsilon-Caprolodone）二甲基丙烯酸酯（PCLDMA）和双丙烯酰基（Bycylylystamine（Bacy）制备一系列新型热反应性生物降解水凝胶（TBHS）。研究了形态，热行为，肿胀/脱离动力学，压缩性能，体外药物递送和生物降解。结果表明，TBHS的性质强烈依赖于温度和PCLDMA与Bacy组分的喂料摩尔比。制备左氧氟沙星（LVF）加载的水凝胶以探讨其刺激响应释放过程。 LVF加载的TBHS的累积释放谱表现出热诱导的缓慢持续的药物释放和还原诱​​导的快速释放。在生理pH下，在谷胱甘肽（GSH）中可以在37℃下缓慢地生物降解。由于它们的均匀孔径，高度互连的架构，可降解的化学和热响应性，本文开发的TBHs对组织工程支架具有高度吸引力应用程序。

著录项

  • 来源
    《RSC Advances》 |2016年第39期|共12页
  • 作者

    Gan Jianqun; Guan XiaoXiao; Zheng Jian; Guo Huilong; Wu Kun; Liang Liyan; Lu Mangeng;

  • 作者单位

    Chinese Acad Sci Key Lab Cellulose &

    Lignocellulos Chem Guangzhou 510650 Guangdong Peoples R China;

    Chinese Acad Sci Key Lab Cellulose &

    Lignocellulos Chem Guangzhou 510650 Guangdong Peoples R China;

    Chinese Acad Sci Key Lab Cellulose &

    Lignocellulos Chem Guangzhou 510650 Guangdong Peoples R China;

    Chinese Acad Sci Key Lab Cellulose &

    Lignocellulos Chem Guangzhou 510650 Guangdong Peoples R China;

    Chinese Acad Sci Key Lab Cellulose &

    Lignocellulos Chem Guangzhou 510650 Guangdong Peoples R China;

    Chinese Acad Sci Key Lab Cellulose &

    Lignocellulos Chem Guangzhou 510650 Guangdong Peoples R China;

    Chinese Acad Sci Key Lab Cellulose &

    Lignocellulos Chem Guangzhou 510650 Guangdong Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号