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首页> 外文期刊>RSC Advances >Mechanical properties, in vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants
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Mechanical properties, in vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants

机译：用于可生物降解植入物的Zn-1.2mg合金的体外降解行为，血液相位性和细胞毒性评价

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摘要

Zn, which is a promising alternative candidate as a biodegradable implant material, possesses excellent biocompatibility and biodegradability. However, the insufficiency of its strength and hardness has largely limited its application. Nevertheless, adding alloying elements and mechanical forming by extrusion have generally enhanced its mechanical properties. In the present work, Zn-1.2Mg alloy has been designed and treated by extrusion. Experimental results demonstrated that the studied alloys were composed of a matrix of Zn and a precipitated phase of Mg2Zn11, and the grain size became smaller and more homogeneous after extrusion. The as-extruded alloy exhibited much higher yield strength (YS 219.61 MPa), ultimate tensile strength (UTS 362.64 MPa), elongation (21.31%) and hardness (96.01 HV). The corrosion rates of the as-extruded alloy were higher compared with those of the as-cast alloy and reached values of 0.19 mm per year in electrochemical tests and 0.11 mm per year after exposure in Hank's solution for 30 days, respectively. Moreover, the as-extruded alloy displayed excellent hemocompatibility (hemolysis rate of 1.85%, superior thromboresistance and no signs of thrombogenicity). The viability of human osteosarcoma HOS cells and MG63 cells cultured in diluted extracts of the alloy exceeded 70%, which demonstrated no potential cytotoxicity and tolerance in cellular applications.
机译：作为可生物降解的植入物质的有前途的替代候选物的Zn具有优异的生物相容性和生物降解性。然而，其强度和硬度的不足主要限于其应用。然而，通过挤出添加合金元素和机械成型通常增强其机械性能。在本工作中，通过挤出设计和处理Zn-1.2mg合金。实验结果表明，所研究的合金由Zn基质和Mg2Zn11的沉淀相组成，并且在挤出后晶粒尺寸变得越来越均匀。挤出合金具有更高的屈服强度（YS 219.61MPa），最终拉伸强度（UTS 362.64MPa），伸长（21.31％）和硬度（96.01HV）。与铸造合金的耐挤出合金的腐蚀速率较高，与铸造合金的腐蚀速率较高，并且在汉克溶液中暴露后每年达到0.19毫米的0.19毫米，分别为30天。此外，用挤出合金显示出优异的血液相色（溶血率为1.85％，优异的血栓球发射率和血栓形成性的迹象）。在合金的稀释萃取液中培养的人骨肉瘤HOS细胞和Mg63细胞的活力超过了70％，其在细胞应用中没有显示出潜在的细胞毒性和耐受性。

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  • 来源
    《RSC Advances》 |2016年第89期|共10页
  • 作者

    Shen Chao; Liu Xiwei; Fan Bo; Lan Pingheng; Zhou Feiyu; Li Xiaokang; Wang Hailiang; Xiao Xin; Li Li; Zhao Shen; Guo Zheng; Pu Zhongjie; Zheng Yufeng;

  • 作者单位

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Harbin Engn Univ Ctr Biomed Mat &

    Engn Harbin 150001 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Lepu Med Technol Co Ltd Bldg 7 37 ChaoQian Rd Beijing 102200 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Harbin Engn Univ Ctr Biomed Mat &

    Engn Harbin 150001 Peoples R China;

    Lepu Med Technol Co Ltd Bldg 7 37 ChaoQian Rd Beijing 102200 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Lepu Med Technol Co Ltd Bldg 7 37 ChaoQian Rd Beijing 102200 Peoples R China;

    Harbin Engn Univ Ctr Biomed Mat &

    Engn Harbin 150001 Peoples R China;

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