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Protective effect of trillin against ethanol-induced acute gastric lesions in an animal model

机译：Trillin对乙醇诱导的动物模型急性胃病变的保护作用

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摘要

The purpose of the present study was to evaluate gastroprotective effect of trillin on mucosal lesions induced by ethanol. Mice were orally administered with trillin (25 mg kg(-1), 50 mg kg(-1), 100 mg kg(-1)) or OME (20 mg kg(-1)). 1 hour later, the mice were intragastrically given ethanol (0.2 ml kg(-1)) and were sacrificed at 4 h after ethanol administration. Compared with the ethanol group, trillin treatment significantly showed increased levels of superoxide dismutase (SOD) in serum, decreased malonaldehyde (MDA) content in serum and decreased activity of myeloperoxidase (MPO) in stomach tissues, which suggested that trillin could prevent oxidative damage. Meanwhile, the serum levels of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) declined after pretreatment with trillin. In HE staining sections, ameliorative pathological changes of gastric lesions were markedly observed in the trillin group compared with those in the ethanol group. In the mechanistic study, the data showed that pretreatment with the trillin also effectively down-regulated protein expressions of p-NF-kappa Bp65, p-I kappa B alpha and COX-2 in stomachs compared with those in the model group. Taken together, it could be concluded that trillin represented a potential therapeutic option to reduce the risk of gastric ulceration.
机译：本研究的目的是评估Trillin对乙醇诱导的粘膜病变的胃保护作用。将小鼠口服用捕获葡ill（25mg kg（-1），50mg kg（-1），100mg kg（-1））或ω（20mg kg（-1））。 1小时后，小鼠胃内给予乙醇（0.2ml kg（-1）），并在乙醇给药后4小时处死。与乙醇基团相比，Trillin治疗显着显示出血清中超氧化物歧化酶（SOD）的水平增加，血清中的马乳醛（MDA）含量降低，胃组织中髓氧化酶（MPO）的活性降低，这表明Trillin可以防止氧化损伤。同时，在用Trillin预处理后，白细胞介素-6（IL-6），白细胞介素-1β（IL-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）的血清水平下降。在染色部分中，与乙醇基团的那些相比，在Trillin组中显着观察到胃病变的改善病理变化。在机械研究中，与模型组中的那些相比，数据显示，与Trillin的预处理也有效地降低了P-NF-Kappa BP65，P-I KappaBα和Cox-2的蛋白表达。连胜，可以得出结论，Trillin代表了降低胃溃疡的潜在治疗选择。

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  • 来源
    《RSC Advances》 |2016年第24期|共8页
  • 作者

    Chen Tong; Jiang Wenjiao; Zhang Huixin; You Xintong; Liu Manling; Wang Linna; Xiang Pengjun; Xu Lijie; Zheng Dongseng; Zhang Xuejiao; Ji Hui; Hao Kun; Yan Tianhua;

  • 作者单位

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    Nanjing Med Univ Dept Neurobiol Nanjing 210029 Peoples R China;

    Nanjing Forestry Univ Dept Polymer Mat &

    Engn Nanjing 210037 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Pharm Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med Nanjing 210009 Peoples R China;

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  • 中图分类 化学;
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