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首页> 外文期刊>RSC Advances >Design, synthesis and in vitro evaluation of anticancer and antibacterial potential of surface modified Tb(OH)(3)@SiO2 core-shell nanoparticles
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Design, synthesis and in vitro evaluation of anticancer and antibacterial potential of surface modified Tb(OH)(3)@SiO2 core-shell nanoparticles

机译：表面改性Tb抗癌和抗菌电位的设计，合成和体外评价（OH）（3）（3）/ / //3） - SiO2核 - 壳纳米粒子

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摘要

In the current study, we modified the surface of Tb(OH)(3) nanoparticles with a silica layer to enhance their solubility and biocompatibility. Transmission electron microscopy confirmed the improvements in these properties. Tb(OH)(3)@SiO2 core-shell nanoparticles (TS-CSNPs) exhibited a strong green emission peak upon irradiation with ultraviolet light, which originates from the electric-dipole transition D-5(4) -> F-7(5) (543 nm) of the Tb3+ ion. In vitro anticancer and antimicrobial activities of the synthesized TS-CSNPs has been evaluated through their potential cytotoxicity and antibacterial activity. TS-CSNPs were shown to have more cytotoxicity against HT29 human colorectal cancer cells with a value of IC50 420.33 in an MTT assay. The alteration of the morphological features of HT29 cells was analysed using various concentrations of TS-CSNPs by inverted microscopy. Western blot analysis results of the apoptotic pathway showed that TS-CSNPs inhibited the growth of HT29 cancer cells through the induction of apoptosis, as evidenced by the down regulation of the expression of anti-apoptotic Bcl-2 and Bcl-xL gene products. Furthermore, the results of the in vitro hemolysis assay with human erythrocytes demonstrated the excellent blood biocompatibility of TS-CSNPs. Our silica coated TS-CSNPs exhibited a non-significant effect on the viability of both Gram negative and Gram positive bacterial strains up to 18 hours of exposure. These results highlight that modified TS-CSNPs can be functionalized to enhance the efficacy of cancer therapeutics due to the significant potential against cancerous cells and antibacterial activity.
机译：在目前的研究中，我们修饰铽（OH）（3）用二氧化硅层的纳米颗粒的表面，以增强它们的溶解性和生物相容性。透射电子显微镜证实了这些特性的改进。铽（OH）（3）@的SiO 2的核 - 壳纳米颗粒（TS-CSNP报文）在用紫外光，照射表现出强的绿色发射峰从电偶极跃迁d-5（4）源自 - > F-7（ 5）Tb3 +的离子的（543纳米）。体外抗癌和合成的TS-CSNP报文的抗菌活性已经通过它们的潜在的细胞毒性和抗菌活性进行评价。 TS-CSNP报文显示具有针对HT29人结肠癌细胞的细胞毒性更在MTT测定一个的IC 50 420.33值。通过倒置显微镜使用各种浓度的TS-CSNP报文的HT29细胞的形态学特征的改变进行了分析。凋亡途径的Western印迹分析结果表明，TS-CSNP报文抑制HT29癌细胞的生长通过细胞凋亡的诱导，由抗细胞凋亡Bcl-2和Bcl-xL基因产物的表达的下调所证明的。此外，与人类的体外溶血测定的结果表明红细胞TS-CSNP报文的优良血液生物相容性。我们的二氧化硅涂覆的TS-CSNP报文显示对革兰氏阴性和革兰氏阳性细菌菌株起来的存活力的非显著效应到18小时的暴露。这些结果强调了改性的TS-CSNP报文可以被官能化，以提高癌症治疗的功效由于针对癌性细胞和抗菌活性的显著潜力。

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  • 来源
    《RSC Advances》 |2016年第22期|共11页
  • 作者

    Khan Shahanavaj; Ansari Anees A.; Khan Abdul Arif; Al-Kattan Wael; Al-Obeed Omar; Ahmad Rehan;

  • 作者单位

    King Saud Univ Coll Pharm Dept Pharmaceut Nanomed &

    Biotechnol Res Unit POB 2457 Riyadh 11451 Saudi Arabia;

    King Saud Univ King Abdullah Inst Nanotechnol POB 2455 Riyadh 11451 Saudi Arabia;

    King Saud Univ Coll Pharm Dept Pharmaceut Nanomed &

    Biotechnol Res Unit POB 2457 Riyadh 11451 Saudi Arabia;

    Al Faisal Univ Dept Surg Riyadh 11451 Saudi Arabia;

    King Saud Univ King Khalid Univ Hosp Coll Med Dept Surg Colorectal Res Chair Riyadh 11451 Saudi Arabia;

    King Saud Univ King Khalid Univ Hosp Coll Med Dept Surg Colorectal Res Chair Riyadh 11451 Saudi Arabia;

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