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首页> 外文期刊>RSC Advances >Preparation of polyetheretherketone composites with nanohydroxyapatite rods and carbon nanofibers having high strength, good biocompatibility and excellent thermal stability
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Preparation of polyetheretherketone composites with nanohydroxyapatite rods and carbon nanofibers having high strength, good biocompatibility and excellent thermal stability

机译：用高强度，良好的生物相容性和优异的热稳定性制备纳米磷灰石杆和碳纳米纤维的聚醚醚酮复合材料

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摘要

In recent years, research in the development of polymeric materials for orthopedic implants has become ever more important because the global demand of biocompatible implants has been steadily increasing. Bioinert polyetheretherketone (PEEK) is typically reinforced with bioactive hydroxyapatite microparticles. However, the tensile strength of conventional PEEK/hydroxyapatite microcomposites falls sharply with increasing filler loading. To address low strength and high filler loading issues, nanohydroxyapatite rods (nHA) and carbon nanofibers (CNF) were employed to reinforce PEEK. In this study, molded-grade PEEK pellets, nHA and CNF fillers were melt-mixed and injection molded to form PEEK/nHA and hybrid PEEK/nHA-CNF nanocomposites. The tensile and thermal properties, as well as the bioactivity and biocompatibility of such nanocomposites, were investigated. Tensile test results showed that elastic modulus of PEEK/nHA nanocomposites increases with increasing nHA content. The PEEK/9.3 vol% nHA nanocomposite exhibited higher tensile strength than that of a conventional HAPEX microcomposite. Thermogravimetric measurements indicated that the nHA addition improves the thermal stability of PEEK. Thus, the PEEK/9.3 vol% nHA nanocomposite that had good mechanical, thermal and biological performances was an attractive biomaterial for use in maxillofacial surgery. Furthermore, the tensile property of the PEEK/15 vol% nHA-1.9 vol% nHA nanocomposite compared favorably with that of human cortical bones. The results of biomineralization, alkaline phosphatase (ALP), 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium (WST-1) assays also showed that the PEEK/15 vol% nHA and PEEK/15 vol% nHA-1.9 vol% CNF nanocomposites exhibited excellent bioactivity and biocompatibility. The ALP assay showed good activity of osteoblast cells on the composite specimens with high nHA content. Moreover, CNF addition further increased the ALP activity of PEEK/15 vol% nHA nanocomposites. The PEEK/15 vol% nHA-1.9 vol% CNF composite, with enhanced tensile strength and excellent biocompatibility, shows large potential for load-bearing implant applications.
机译：近年来，在整形外科植入物的聚合物材料开发的研究变得更加重要，因为生物相容性植入物的全球需求已经稳步增加。 Bioinert聚醚醚酮（PEEK）通常用生物活性羟基磷灰石微粒加固。然而，常规PEEK /羟基磷灰石微相复合材料的拉伸强度随着填料载荷的增加而急剧下降。为了解决低强度和高填充物装载问题，使用纳米羟基磷灰石棒（NHA）和碳纳米纤维（CNF）来加强PEEK。在该研究中，模塑级PEEK颗粒，NHA和CNF填料熔融混合和注塑以形成PEEK / NHA和杂交PEEK / NHA-CNF纳米复合材料。研究了拉伸和热性能，以及这种纳米复合材料的生物活性和生物相容性。拉伸试验结果表明，PEEK / NHA纳米复合材料的弹性模量随着NHA含量的增加而增加。 PEEK / 9.3 Vol％NHA纳米复合材料表现出比常规HAPEX微型复合材料更高的拉伸强度。热重度测量表明，NHA添加提高了PEEK的热稳定性。因此，PEEK / 9.3 Vol％NHA纳米复合材料具有良好的机械，热和生物学性能是一种有吸引力的生物材料，用于颌面外科。此外，PEEK / 15体积％NHA-1.9 Vol％NHA纳米复合材料的拉伸性能有利地与人皮质骨骼的效果相比。生物丙原化，碱性磷酸酶（ALP），3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴铵（MTT）和2-（4-碘苯基）-3-（4-硝基苯）的结果-5-（2,4-二苯基苯基）-2H-四唑（WST-1）测定还表明，PEEK / 15体积％NHA和PEEK / 15 VOL％NHA-1.9 Vol％CNF纳米复合材料表现出优异的生物活性和生物相容性。 ALP测定显示出具有高NHA含量的复合标本上的成骨细胞良好的活性。此外，CNF添加进一步增加了PEEK / 15 Vol％NHA纳米复合材料的ALP活性。 PEEK / 15 VOL％NHA-1.9 Vol％CNF复合材料，具有增强的拉伸强度和优异的生物相容性，显示出承载承载植入物应用的大量电位。

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  • 来源
    《RSC Advances》 |2016年第23期|共13页
  • 作者

    Chan Kai Wang; Liao Cheng Zhu; Wong Hoi Man; Yeung Kelvin Wai Kwok; Tjong Sie Chin;

  • 作者单位

    City Univ Hong Kong Dept Phys &

    Mat Sci Tat Chee Ave Kowloon Hong Kong Peoples R China;

    South Univ Sci &

    Technol China Dept Mat Sci &

    Engn Shenzhen Peoples R China;

    Univ Hong Kong Li Ka Shing Fac Med Dept Orthoped &

    Traumatol Hong Kong Hong Kong Peoples R China;

    Univ Hong Kong Li Ka Shing Fac Med Dept Orthoped &

    Traumatol Hong Kong Hong Kong Peoples R China;

    City Univ Hong Kong Dept Phys &

    Mat Sci Tat Chee Ave Kowloon Hong Kong Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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