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A highly selective ratiometric fluorescent probe for biothiol and imaging in live cells

机译：用于生物醇的高度选择性的比例荧光探针和活细胞中的成像

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摘要

A new N-butyl-4-amino-1,8-naphthalimide-based colorimetric and ratiometric fluorescent probe for the detection of biothiols (cysteine, homocysteine, and glutathione) was designed and synthesized. The probe exhibited good selectivity and sensitivity toward biothiols over other non-thiol-bearing amino acids and common anions with significant changes in both color (from colorless to yellow) and fluorescence (from blue to yellow-green). The mechanism is based on cleavage of disulfide by thiols followed by an intramolecular cyclization to give the product, N-butyl-4-amino-1,8-naphthalimide, which showed outstanding intramolecular charge transfer (ICT). Therefore, ratiometric fluorescence signal was observed. Furthermore, the probes were successfully applied for visualizing endogenous thiols in living cells.
机译：设计并合成了用于检测生物醇（半胱氨酸，半胱氨酸和谷胱甘肽）的新的正丁基-4-氨基-1,8-萘基的比色和分量荧光探针。 探针表现出良好的选择性和敏感性，在其他非硫醇轴承的氨基酸和常见阴离子上具有良好的阴离子，具有两种颜色（从无色至黄色）和荧光（从蓝色到黄绿色）的显着变化。 该机制基于硫醇的裂解，硫醇随后是分子内的环化，得到产物，N-丁基-4-氨基-1,8-萘酰亚胺，其显示出优异的分子内电荷转移（ICT）。 因此，观察到比例荧光信号。 此外，成功地施加探针以在活细胞中可视化内源硫醇。

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  • 来源
    《RSC Advances》 |2016年第49期|共6页
  • 作者

    Gao Baozhen; Cui Lixia; Pan Yong; Zhang Guomei; Zhou Ying; Zhang Caihong; Shuang Shaomin; Dong Chuan;

  • 作者单位

    Shanxi Univ Dept Chem &

    Chem Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Dept Chem &

    Chem Engn Taiyuan 030006 Peoples R China;

    Res Inst Chem Def State Key Lab NBC Protect Civilian Beijing 102205 Peoples R China;

    Shanxi Univ Dept Chem &

    Chem Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Dept Chem &

    Chem Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Dept Chem &

    Chem Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Dept Chem &

    Chem Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Dept Chem &

    Chem Engn Taiyuan 030006 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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