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Biofilm formation in total hip arthroplasty: prevention and treatment

机译:总髋关节置换术的生物膜形成:预防和治疗

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摘要

Biomaterials science is a very active area of research, which has allowed the successful use of implants in the orthopaedic field for over a century. However, implant infection remains a clinical concern as it is associated with extensive patient morbidity and a high economic burden, which is predicted to increase due to an ageing population. Bacteria are able to adhere, colonise and develop into biofilms on the surface of biomaterials making associated infections physiologically different to other post-surgical infections. Unfortunately, biofilms exert increased protection from the host immune system and an increased resistance to antibiotic therapy in comparison to their planktonic counterparts. The aim of this review is to assess the current knowledge on treatments, pathogenesis and the prevention of infections associated with orthopaedic implants, with a focus on total hip arthroplasty.
机译:生物材料科学是一个非常活跃的研究领域,允许在整个世纪以来的骨科领域成功使用植入物。 然而,植入感染仍然是临床关注,因为它与广泛的患者发病率和高经济负担有关,这预计由于人口老龄化而增加。 细菌能够在生物材料表面上粘附,殖民和发展成为生物材料表面,使得相关感染与其他手术后感染不同的感染。 不幸的是,生物膜与宿主免疫系统的保护效果增加,并与其浮游对应物相比,对抗生素治疗的增加。 本综述的目的是评估目前关于治疗,发病机制和预防与骨科植入物相关的感染的知识,重点关注总髋关节置换术。

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  • 来源
    《RSC Advances》 |2016年第83期|共18页
  • 作者单位

    Mt Vernon Hosp RAFT Inst Plast Surg Leopold Muller Bldg Northwood HA6 2RN Middx England;

    Univ Coll London Royal Natl Orthopaed Hosp Div Surg &

    Intervent Sci John Scales Ctr Biomed Engn Inst Orthopaed &

    Musc Stanmore HA7 4LP Middx England;

    Mt Vernon Hosp RAFT Inst Plast Surg Leopold Muller Bldg Northwood HA6 2RN Middx England;

    Univ Coll London Royal Natl Orthopaed Hosp Div Surg &

    Intervent Sci John Scales Ctr Biomed Engn Inst Orthopaed &

    Musc Stanmore HA7 4LP Middx England;

    Univ Coll London Royal Natl Orthopaed Hosp Div Surg &

    Intervent Sci John Scales Ctr Biomed Engn Inst Orthopaed &

    Musc Stanmore HA7 4LP Middx England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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