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首页> 外文期刊>RSC Advances >Enduring protection provided by NMITLI118RT+ and its preparation NMITLI118RT+CFM against ischemia/reperfusion injury in rats
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Enduring protection provided by NMITLI118RT+ and its preparation NMITLI118RT+CFM against ischemia/reperfusion injury in rats

机译：由Nmitli118RT +提供的持久保护及其制备Nmitli118RT + CFM免受大鼠缺血/再灌注损伤的影响

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摘要

Withania somnifera Dunal (Ashwagandha), is an Indian medicinal plant with significant pharmacological properties. Withanolides (steroidal lactones) are the chief constituents potentially responsible for its activity. Some of its chemotypes includes NMITLI-101, NMITLI-118, NMITLI-128. The present work elaborates the optimization and development of a ready to fill capsule powder blend (NMITLI118RT+CFM) for efficient delivery of NMITLI118RT+ (a standardized extract of a new chemotype of Withania somnifera Dunal) and to investigate their protective effects against cerebral stroke in rats. NMITLI118RT+CFM was prepared by solid liquid compacting technique and filled into capsules; it was characterized on the basis of loss on drying, flow properties, IR, disintegration time, weight variation, content uniformity and DSC analysis. NMITLI118RT+ and NMITLI118RT+CFM were evaluated for biological activity utilizing middle cerebral artery occlusion model in rats. NMITLI118RT+CFM was found to be pharmaceutically acceptable. Results showed that NMITLI118RT+ and NMITLI118RT+CFM possess significant neuroprotective activity against cerebral ischemia at 50 mg kg(-1) in rats. NMITLI118RT+ and its pharmaceutical compositions exhibit sufficient biological promise for management of cerebral stroke. The investigation discloses potent and prudent therapeutic potential of a new formulation using standardized fraction of a new variety of Withania somnifera (NMITLI118RT+) for brain function restoration and protection from neurological failures.
机译：WITANIA SOMNIFERA DUNAL（ASHWAGANDHA）是印度药用植物，具有重要的药理学性质。甘蔗糖苷（甾体内酯）是可能对其活性负责的主要成分。其一些化学型包括Nmitli-101，Nmitli-118，Nmitli-128。本工作阐述了准备填充胶囊粉末混合物（NMITLI118RT + CFM）的优化和开发，以便有效地递送Nmitli118RT +（一种新的含有含有含有Somnifera Dunal的新趋化酶的标准化提取物），并调查其对大鼠脑卒中的保护作用。 NMITLI118RT + CFM通过固体液体压实技术制备并填充到胶囊中;其特征在于干燥，流动性，IR，崩解时间，重量变异，含量均匀性和DSC分析的损失。利用大鼠中脑动脉闭塞模型评价NMITLI118RT +和NMITLI118RT + CFM。发现NMITLI118RT + CFM是药学上可接受的。结果表明，NMITLI118RT +和NMITLI118RT + CFM对大鼠50mg kg（-1）的脑缺血具有显着的神经保护活性。 NMITLI118RT +及其药物组合物对脑卒中的管理表现出充分的生物学许可。该研究公开了利用新品种的含有含有新的含有含有含有含有新的血清素（Nmitli118RT +）的新配方的有效和谨慎的治疗潜力，用于脑功能恢复和免受神经故障的保护。

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  • 来源
    《RSC Advances》 |2016年第49期|共9页
  • 作者

    Ahmad Hafsa; Samuel Sheeba Saji; Khandelwal Kiran; Arya Abhishek; Tripathi Shivangi; Agrawal Satish; Sangwan Neelam Singh; Shukla Rakesh; Dwivedi Anil Kumar;

  • 作者单位

    CSIR Cent Drug Res Inst Div Pharmaceut PCS 001-11 Sect 10 BS 10-1 Lucknow 226031 Uttar Pradesh India;

    CSIR Cent Drug Res Inst Div Pharmaceut PCS 001-11 Sect 10 BS 10-1 Lucknow 226031 Uttar Pradesh India;

    CSIR Cent Drug Res Inst Div Pharmaceut PCS 001-11 Sect 10 BS 10-1 Lucknow 226031 Uttar Pradesh India;

    CSIR Cent Drug Res Inst Div Pharmaceut PCS 001-11 Sect 10 BS 10-1 Lucknow 226031 Uttar Pradesh India;

    CSIR Cent Drug Res Inst Div Pharmaceut PCS 001-11 Sect 10 BS 10-1 Lucknow 226031 Uttar Pradesh India;

    CSIR Cent Drug Res Inst Div Pharmaceut PCS 001-11 Sect 10 BS 10-1 Lucknow 226031 Uttar Pradesh India;

    CSIR CDRI Div Pharmacol Lucknow Uttar Pradesh India;

    CSIR Cent Drug Res Inst Div Pharmaceut PCS 001-11 Sect 10 BS 10-1 Lucknow 226031 Uttar Pradesh India;

    CSIR Cent Drug Res Inst Div Pharmaceut PCS 001-11 Sect 10 BS 10-1 Lucknow 226031 Uttar Pradesh India;

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  • 中图分类 化学;
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