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Magnetic nanoporous hybrid carbon from core-shell metal-organic frameworks for glycan extraction

机译:来自核 - 壳金属 - 有机框架的磁性纳米孔杂交碳用于聚糖提取

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摘要

Magnetic nanoporous carbon (NPC) materials, which can be thoroughly separated from an aqueous solution easily, are very promising adsorbents. In this study, magnetic nanoporous hybrid carbon materials were synthesized as a novel enrichment platform for glycan analysis using core-shell metal-organic frameworks (MOFs) as a sacrificial template and carbon precursor. The designed and synthesized magnetic nanoporous hybrid carbon materials possessed hybrid merits, including high surface area, cut-off effect of uniform pore size, high graphitic carbon content and strong magnetic response. Considering the specific interaction between graphitized carbons and glycan, the magnetic nanoporous hybrid carbon materials with good repeatability were successfully used to enrich N-glycans from both standard protein digests and human serum.
机译:磁性纳米孔碳(NPC)材料可以容易地与水溶液彻底分离,是非常有前景的吸附剂。 在该研究中,使用核 - 壳金属 - 有机骨架(MOF)作为牺牲模板和碳前体,作为聚糖分析的新富集平台合成磁性纳米孔杂交碳材料。 设计和合成的磁性纳米孔杂交碳材料具有杂交优点,包括高表面积,均匀孔径的切断效果,高石墨碳含量和强磁响应。 考虑到石墨化碳碳和聚糖之间的特定相互作用,成功地成功地使用具有良好重复性的磁性纳米孔杂化碳材料来富含标准蛋白质消化和人血清的N-聚糖。

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  • 来源
    《RSC Advances》 |2016年第41期|共5页
  • 作者单位

    Fudan Univ Dept Chem Shanghai 200433 Peoples R China;

    Fudan Univ Dept Chem Shanghai 200433 Peoples R China;

    Fudan Univ Dept Chem Shanghai 200433 Peoples R China;

    Fudan Univ Dept Chem Shanghai 200433 Peoples R China;

    Fudan Univ Sch Pharm Pharmaceut Anal Dept Shanghai 201203 Peoples R China;

    Fudan Univ Dept Chem Shanghai 200433 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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