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首页> 外文期刊>RSC Advances >A FRET-based fluorescent approach for labetalol sensing using calix[6]arene functionalized MnO2@graphene as a receptor
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A FRET-based fluorescent approach for labetalol sensing using calix[6]arene functionalized MnO2@graphene as a receptor

机译：使用CALIX [6]芳烃官能化MNO2 @ Graphene作为受体的荧光酚感测的荧光荧光方法

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摘要

A turn-on fluorescent sensing platform for labetalol determination has been developed based on competitive host-guest interaction between p-sulfonated calix[6] arene (SCX6) and signal probe/target molecules by using SCX6 functionalized MnO2@reduced graphene oxide (SCX6-MnO2@RGO) as a receptor. Rhodamine 6G (R6G) and labetalol were selected as the probe and target molecules, respectively. When R6G enters into the SCX6 host, its fluorescence is quenched by MnO2@RGO. However, on addition of labetalol to the preformed R6G.SCX6-MnO2@RGO complex, the R6G molecule is displaced by labetalol from the host of SCX6, leading to a "switch-on" fluorescence response. This is due to the fact that the binding constant of the labetalol/SCX6 complex is much higher than that of R6G/SCX6. The fluorescence intensity of the SCX6-MnO2@RGO$ R6G complex increased linearly with increasing concentration of labetalol ranging from 1.0 to 18.0 mu M. The proposed method showed a detection limit of 0.25 mu M for labetalol. In addition, 2D NMR and molecular modeling studies indicated that the salicylamide part of the labetalol molecule inserted into the cavity of SCX6, while the phenylpropyl group located outside of the SCX6 host.
机译：通过使用SCX6官能化MNO2 @ Dreame氧化石墨烯（SCX6- mno2 @ rgo）作为受体。选择罗丹明6G（R6G）和Labetalol分别作为探针和靶分子。当R6G进入SCX6宿主时，其荧光由MNO2 @ Rgo淬火。然而，在将Labetalol添加到预先形成的R6G.SCX6-MNO2@rgo复合物中，R6G分子由Labetalol从SCX6的宿主移位，导致“接通”荧光反应。这是由于Labetalol / SCX6复合物的结合常数远高于R6G / SCX6的结合常数。 SCX6-MNO2 @ RGO rgo复合物的荧光强度随着较小的浓度为1.0至18.0μm的Labetalol浓度的浓度而增加。所提出的方法显示出对Labetalol0.25μm的检出限。此外，2D NMR和分子建模研究表明，将Labetalol分子的水杨酰胺部分插入SCX6的腔体中，而位于SCX6宿主外部的苯基丙基。

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  • 来源
    《RSC Advances》 |2016年第83期|共11页
  • 作者

    Ye Hanzhang; Yang Long; Zhao Genfu; Zhang Yanqiong; Ran Xin; Wu Shilian; Zou Suo; Xie Xiaoguang; Zhao Hui; Li Can-Peng;

  • 作者单位

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

    Yunnan Univ Lab Conservat &

    Utilizat Bioresource Kunming 650091 Peoples R China;

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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