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Handling and managing bleeding wounds using tissue adhesive hydrogel: a comparative assessment on two different hydrogels

机译:使用组织粘合剂水凝胶处理和管理出血伤口:两种不同水凝胶的比较评估

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摘要

The present study explores the preparation and a comparative assessment on the physical, mechanical and biological properties of two different tissue adhesive hydrogels (TAHs) for the management of bleeding wounds. TAHs were prepared through tethering of di-/tri-hydroxyl phenolics to a gelatin backbone and subjected to oxidation. It has been observed that all the physical, mechanical and biological properties are at significant levels upon tri-hydroxyl phenolic functionalization rather than di-hydroxyl phenolic functionalization. The considerable hemostatic activity and adhesive strength of the hydrogel upon functionalization with phenolic acids controls the blood loss and supports the early healing of bleeding wounds. In conclusion, functionalization with tri-hydroxyl phenolics imparts hemostatic, adhesive strength and tissue approximation properties of gelatin, which solves most of the problems associated with the management of bleeding wounds.
机译:本研究探讨了两种不同组织粘合剂水凝胶(TAHS)的物理,机械和生物学性能的比较评估,用于管理出血伤口。 通过将二羟基酚醛蛋白的束缚成明胶骨架并进行氧化来制备TAHS。 已经观察到所有物理,机械和生物学性质在三羟基酚官能化而不是二羟基酚醛官能化上的显着水平。 水凝胶在酚酸官能化上的相当大的止血活性和粘合强度对抗血液损失并支持出血伤口的早期愈合。 总之,用三羟基酚菌素的官能化赋予明胶的止血,粘合强度和组织近似性质,其解决了与出血伤口的管理相关的大多数问题。

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  • 来源
    《RSC Advances》 |2016年第24期|共9页
  • 作者单位

    Cent Leather Res Inst CSIR Madras 20 Tamil Nadu India;

    Cent Leather Res Inst CSIR Madras 20 Tamil Nadu India;

    Cent Leather Res Inst CSIR Madras 20 Tamil Nadu India;

    Cent Leather Res Inst CSIR Madras 20 Tamil Nadu India;

    Cent Leather Res Inst CSIR Madras 20 Tamil Nadu India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

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