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Constructing H+-triggered bubble generating nano-drug delivery systems using bicarbonate and carbonate

机译：用碳酸氢盐和碳酸酯构建H +触发的气泡产生纳米药物递送系统

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摘要

Nanoparticles have the great potential to act as drug delivery carriers, and such systems must effectively deliver the drug to the cancer cells, and provide intracellular drug release. In this research, two types of H+-triggered bubble generating nanosystems (BGNS) were developed which were obtained using hollow mesoporous silica nanoparticles loaded with doxorubicin and subsequently treated with bubble generating agents, i.e., sodium bicarbonate (SBC) and ammonium carbonate (AC). These were named BGNS-SBC and BGNS-AC. After internalization by the tumor cells, the H+ reacts with bicarbonate or carbonate to generate carbon dioxide bubbles quickly in an acidic environment of endo/lysosomes, which results in lysosomal membrane permeabilization (LMP). Then, the enhanced LMP induced cancer cell death by an apoptosis-like pathway because of the release of caspase-3 from the lysosome into the cytoplasm. In addition, BGNS-SBC and BGNS-AC possessed remarkable cytotoxicity against MCF-7 cells and efficiently overcame the multidrug resistance (MDR) of MCF-7/adriamycin cells. Therefore, these bubble generating nanosystems could be a promising nanocarrier for the treatment of tumors.
机译：纳米粒子具有充当药物递送载体的潜力巨大潜力，这种系统必须有效地将药物递送给癌细胞，并提供细胞内药物释放。在该研究中，开发了两种类型的H +触发气泡产生纳米系统（BGNS），其使用加载有多柔比星的中空介孔二氧化硅纳米粒子获得并随后用气泡发生剂处理，即碳酸氢钠（SBC）和碳酸铵（AC）处理。这些被命名为BGNS-SBC和BGNS-AC。在肿瘤细胞内化后，H +与碳酸氢盐或碳酸酯反应，以在内部/溶酶体的酸性环境中快速产生二氧化碳气泡，这导致溶酶体膜透化（LMP）。然后，由于从溶酶体中释放到细胞质中，通过凋亡样途径增强LMP诱导的癌细胞死亡。此外，BGNS-SBC和BGNS-AC对MCF-7细胞具有显着的细胞毒性，并有效地克服MCF-7 / Adriamycin细胞的多药耐药性（MDR）。因此，这些气泡产生纳米系统可以是用于治疗肿瘤的有前途的纳米载体。

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  • 来源
    《RSC Advances》 |2016年第107期|共7页
  • 作者

    Wen Zuhuang; Long Yijuan; Yang Lili; Hu Jiangang; Huang Ning; Cheng Yuan; Zhao Li; Zheng Huzhi;

  • 作者单位

    Southwest Univ Coll Chem &

    Chem Engn Key Lab Luminescent &

    Real Time Analyt Chem Chongqing 400715 Peoples R China;

    Southwest Univ Coll Chem &

    Chem Engn Key Lab Luminescent &

    Real Time Analyt Chem Chongqing 400715 Peoples R China;

    Southwest Univ Coll Chem &

    Chem Engn Key Lab Luminescent &

    Real Time Analyt Chem Chongqing 400715 Peoples R China;

    Chongqing Med Univ Dept Neurosurg Affiliated Hosp 2 Chongqing 400010 Peoples R China;

    Chongqing Med Univ Dept Neurosurg Affiliated Hosp 2 Chongqing 400010 Peoples R China;

    Chongqing Med Univ Dept Neurosurg Affiliated Hosp 2 Chongqing 400010 Peoples R China;

    Southwest Univ Southwest Univ Hosp Chongqing 400715 Peoples R China;

    Southwest Univ Coll Chem &

    Chem Engn Key Lab Luminescent &

    Real Time Analyt Chem Chongqing 400715 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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