Potentially antibreast cancer enamidines via azide-alkyne-amine coupling and their molecular docking studies

Bansode Prakash; Jadhav Jagannath; Kurane Rajanikant; Choudhari Prafulla; Bhatia Manish; Khanapure Sharanabasappa; Salunkhe Rajashri; Rashinkar Gajanan

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Potentially antibreast cancer enamidines via azide-alkyne-amine coupling and their molecular docking studies

机译：潜在的抗纤维癌酯氨基氨基酰胺偶联及其分子对接研究

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An attempt to prepare a new triazole series by Cu catalyzed multicomponent reactions of tosyl azide, propargyl bromide and secondary amines led to the synthesis of enamidines. All the synthesized enamidines were evaluated for antiproliferative activities. The four molecules 4a-c and 4h showed higher anticancer activity with GI(50) values less than the standard drug doxorubicin against human breast cancer cell line MCF-7. The virtual analysis ascertains the mode of action of these compounds via inhibition of human cell division protein kinase7 (CDK7).

机译：试图通过Cu催化甲酰胺，溴化丙基和仲胺的Cu催化的多组分反应制备新的三唑级系列导致酯氨基脒的合成。对抗增殖活动评估所有合成的嵌入品。四个分子4a-c和4h显示出比人乳腺癌细胞系MCF-7的标准药物多柔比星的GI（50）值更高的抗癌活性。虚拟分析通过抑制人细胞分裂蛋白激酶7（CDK7）来确定这些化合物的作用方式。

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来源
《RSC Advances》 |2016年第93期|共10页
作者
Bansode Prakash; Jadhav Jagannath; Kurane Rajanikant; Choudhari Prafulla; Bhatia Manish; Khanapure Sharanabasappa; Salunkhe Rajashri; Rashinkar Gajanan;
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Shivaji Univ Dept Chem Kolhapur 416004 Maharashtra India;

Shivaji Univ Dept Chem Kolhapur 416004 Maharashtra India;

Shivaji Univ Dept Chem Kolhapur 416004 Maharashtra India;

Bharati Vidyapeeth Coll Pharm Dept Pharmaceut Chem Kolhapur 416013 Maharashtra India;

Bharati Vidyapeeth Coll Pharm Dept Pharmaceut Chem Kolhapur 416013 Maharashtra India;

Shivaji Univ Dept Chem Kolhapur 416004 Maharashtra India;

Shivaji Univ Dept Chem Kolhapur 416004 Maharashtra India;

Shivaji Univ Dept Chem Kolhapur 416004 Maharashtra India;

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正文语种 eng
中图分类化学;
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1. Potentially antibreast cancer enamidines via azide-alkyne-amine coupling and their molecular docking studies [J] . Bansode Prakash, Jadhav Jagannath, Kurane Rajanikant, RSC Advances . 2016,第93期

机译：潜在的抗纤维癌酯氨基氨基酰胺偶联及其分子对接研究
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Potentially antibreast cancer enamidines via azide-alkyne-amine coupling and their molecular docking studies

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