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首页> 外文期刊>RSC Advances >Poly(gamma-glutamic acid) induced homogeneous mineralization of the poly(ethylene glycol)-co-2-hydroxyethyl methacrylate cryogel for potential application in bone tissue engineering
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Poly(gamma-glutamic acid) induced homogeneous mineralization of the poly(ethylene glycol)-co-2-hydroxyethyl methacrylate cryogel for potential application in bone tissue engineering

机译：聚（γ-谷氨酸）诱导聚（乙二醇）-Co-2-羟乙基甲基丙烯酸酯冷冻凝胶的均匀矿化，用于骨组织工程中的潜在应用

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摘要

Methacrylated poly(gamma-glutamic acid) (mPGA) was introduced to the spongy poly(ethylene glycol)-co-2-hydroxyethyl methacrylate (PEG-HEMA) cryogels. A suitable amount (<0.1% w/v) of poly(gamma-glutamic acid) (gamma-PGA) in cryogels was found to promote homogeneous mineralization, while higher concentration of gamma-PGA inhibited the mineralization. The deposited minerals mainly consisted of hydroxyapatite, carbonated apatite, and calcium phosphate, and were independent on the concentration of gamma-PGA. The mineralized cryogels can support adhesion, viability, and migration of rat bone marrow stromal cells (rMSCs). The gamma-PGA/HEMA-PEGDA cryogels showed their great potential as promising scaffolding materials in bone tissue engineering.
机译：将甲基丙烯酸酯化的聚（γ-谷氨酸）（MPGA）引入海绵状聚（乙二醇）-2-羟乙基甲基丙烯酸酯（PEG-HEMA）Cryogels。 发现在冷冻胶中的合适量（<0.1％w / v）多（γ-谷氨酸）（γ-pga）促进均匀的矿化，而较高浓度的γ-pga抑制了矿化。 沉积的矿物质主要由羟基磷灰石，碳酸化物和磷酸钙组成，并与γ-PGA的浓度无关。 矿化冷冻机可支持大鼠骨髓基质细胞（RMSCs）的粘附性，活力和迁移。 Gamma-PGA / Hema-PEGDA Cryogels在骨组织工程中显示出巨大的脚手架材料。

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  • 来源
    《RSC Advances》 |2015年第26期|共7页
  • 作者

    Liu Chuntao; Liu Xin; Quan Changyun; Li Xiaoqiong; Chen Chaozhu; Kang Hua; Hu Weikang; Jiang Qing; Zhang Chao;

  • 作者单位

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Engn Guangzhou 510006 Guangdong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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