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A microRNAs-mRNAs network involved in the control of graphene oxide toxicity in Caenorhabditis elegans

机译：涉及Caenorhabdise Labs中的石墨烯氧化物毒性控制的MicroRNAS-MRNA网络

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摘要

A previous study has suggested that microRNAs (miRNAs) are involved in the control of the toxicity of graphene oxide (GO) in the in vivo Caenorhabditis elegans assay system. However, it is still unclear for miRNAs-mRNAs networks functioning to regulate GO toxicity. In the present study, we first employed a HiSeq 2000 sequencing technique to examine dysregulated mRNAs in GO-exposed nematodes and identified 970 up-regulated and 995 down-regulated mRNAs. Analysis of both gene ontology and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway implied that these dysregulated mRNAs mediated many important biological processes. Some dysregulated genes encode the JNK signaling pathway, which was proven to be involved in the control of GO toxicity. In the JNK signaling pathway, JKK-1 and MEK-1 function in the same pathway as JNK-1 to regulate GO toxicity. Moreover, we raised a miRNAs-mRNAs network, which at least potentially explained molecular basis for the roles of oxidative stress, intestinal barrier, and defecation behavior in regulating GO toxicity. The established link between miRNAs and mRNAs provides the key basis for further elucidating the molecular mechanisms of GO toxicity in organisms.
机译：先前的研究表明，MicroRNAS（miRNA）参与控制石墨烯氧化物（GO）的毒性（GO）在体内CAENORHABDIOLABS测定系统中。然而，对于MiRNA-MRNA网络运行来调节毒性尚不清楚。在本研究中，我们首先使用Hiseq 2000测序技术来检查暴露的线虫中的失调MRNA，并确定了970个上调和995个下调的MRNA。对基因本体和基因的京都植物和基因组（KEGG）途径的分析暗示了这些失去的MRNA介导许多重要的生物过程。一些疑难解理的基因编码JNK信号通路，被证明是涉及控制毒性的控制。在JNK信令路径中，JKK-1和MEK-1在与JNK-1相同的路径中的功能，以调节GO毒性。此外，我们提出了MiRNA-MRNA网络，该网络至少潜在地解释了氧化应激，肠道屏障和排序行为在调节毒性方面的作用的分子基础。 MiRNA和MRNA之间的已建立的联系提供了进一步阐明生物体中毒性的分子机制的关键基础。

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  • 来源
    《RSC Advances》 |2015年第112期|共12页
  • 作者

    Zhao Yunli; Wu Qiuli; Wang Dayong;

  • 作者单位

    Southeast Univ Sch Med Nanjing 210009 Jiangsu Peoples R China;

    Southeast Univ Sch Med Nanjing 210009 Jiangsu Peoples R China;

    Southeast Univ Sch Med Nanjing 210009 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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