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首页> 外文期刊>RSC Advances >Surface modification of intraocular lenses with hyaluronic acid and lysozyme for the prevention of endophthalmitis and posterior capsule opacification
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Surface modification of intraocular lenses with hyaluronic acid and lysozyme for the prevention of endophthalmitis and posterior capsule opacification

机译：具有透明质酸和溶菌酶的眼内晶状体的表面改性，用于预防眼球炎和后胶囊渗透

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摘要

Posterior capsule opacification is one of the complications of cataract surgery caused by the adhesion and reproduction of residual human lens epithelial cells (HLECs) on the posterior capsule. Infectious endophthalmitis is another common complication due to bacterial colonization and biofilm formation. Hyaluronic acid-lysozyme (HA-lysozyme) composite coating was covalently grafted on the surface of PMMA intraocular lenses by reaction with N-hydroxysuccinimide (NHS) and 1-etil-3-(3-dimetilaminopropil) carbodiimida (EDC). Measurements of water contact angle and AFM revealed that the coating created a highly hydrophilic surface with low roughness. Adherences of S. aureus and HLECs on PMMA with HA or HA-lysozyme coating were significantly reduced due to the hydrophilic property of HA. Bactericidal activity of HA-lysozyme coatings, measured by SEM and LIVE/DEAD bacterial viability kit, was remarkably effective against S. aureus owing to the component of lysozyme. The achievement of the HA-lysozyme composite coating with anti-adhesive and antibacterial properties can potentially be widely used on surface modification of PMMA intraocular lenses and other biomedical implants.
机译：后囊膜混浊是由在后囊的粘附和残留人晶状体上皮细胞（HLECs）的再现白内障手术的并发症之一。感染性眼内炎是另一种常见的并发症是由于细菌定植和生物膜形成。透明质酸 - 溶菌酶（HA-溶菌酶）复合涂层共价通过与N-羟基琥珀酰亚胺（NHS）和1- ETIL -3-（3- dimetilaminopropil）carbodiimida（EDC）反应的接枝的PMMA眼内透镜的表面上。水接触角和AFM的测量结果表明，该涂层产生的亲水性高的表面具有低粗糙度。金黄色葡萄球菌的坚持，HLECs在PMMA与HA或HA-溶菌酶涂层被显著由于HA的亲水性降低。 HA-溶菌酶涂层，通过SEM和LIVE / DEAD细菌活力试剂盒测定的杀菌活性，反对由于溶菌酶的成分的金黄色葡萄球菌显着有效。与抗粘连性和抗菌性的HA-溶菌酶复合涂料的成就可以潜在地对PMMA眼内镜片和其它生物医学植入物的表面改性得到广泛应用。

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  • 来源
    《RSC Advances》 |2015年第5期|共8页
  • 作者

    Wang Bailiang; Lin Quankui; Jin Tingwei; Shen Chenghui; Tang Junmei; Hana Yuemei; Chen Hao;

  • 作者单位

    Wenzhou Med Univ Hosp Eye Sch Ophthalmol &

    Optometry Wenzhou 325027 Peoples R China;

    Wenzhou Med Univ Hosp Eye Sch Ophthalmol &

    Optometry Wenzhou 325027 Peoples R China;

    Wenzhou Univ City Coll Dept Basic Teaching Wenzhou 325027 Peoples R China;

    Chinese Acad Sci Wenzhou Inst Biomat &

    Engn Wenzhou 32500 Peoples R China;

    Wenzhou Med Univ Hosp Eye Sch Ophthalmol &

    Optometry Wenzhou 325027 Peoples R China;

    Wenzhou Med Univ Hosp Eye Sch Ophthalmol &

    Optometry Wenzhou 325027 Peoples R China;

    Wenzhou Med Univ Hosp Eye Sch Ophthalmol &

    Optometry Wenzhou 325027 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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