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Modulating the elution of antibiotics from nanospongy titanium surfaces with a pH-sensitive coating

机译：用pH敏感涂层调节抗生素的抗生素洗脱

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Metals currently used for prosthetic reconstructions enjoy a relatively good success rate, but post-surgical infections still remain an important challenge. In addition, there are still no such metals that are able to respond to any deterioration of their relationship with the host tissue, in particular to an acidification of the local environment, an event associated to bone remodeling, tissue inflammation and bacterial infection. Distinctive from previous work that employed anodization of titanium to engender nanotubular structures, we exploited this technique to create a nanospongy surface that behaved as a non-eroding drug-eluting template for the extended release of vancomycin, a model antibiotic. Successively, as a proof of concept, we employed a chitosan-poly(ethylene glycol) (PEG) coating to provide pH-dependent release kinetics of vancomycin molecules stored in the underlying 3-dimensional network of nanometric pores. A physicochemical characterization of the polymeric blend by ATR-FTIR and DPFM-AFM unveiled its morphological and nanomechanical characteristics and permitted to link them to its stability and swelling behavior in aqueous solutions at three different pHs. This study demonstrates the ability of nanospongy titanium surfaces to provide extended elution of vancomycin, one of the most effective antibiotics against Gram-positive bacteria, for over one week, thus becoming a valid alternative to existing drug-eluting metallic platforms. In addition, our results show how the elution profiles can be modulated to respond to an acidification of the surrounding environment by exploiting uncross-linked and cross-linked chitosan-PEG coatings, ultimately paving the way for their broader use as a versatile coating for nanoporous drug-delivery platforms.
机译：目前用于假肢重建的金属享有相对良好的成功率，但外科后感染仍然是一个重要的挑战。此外，仍然没有这种金属能够响应与宿主组织的关系的任何恶化，特别是局部环境的酸化，与骨重塑，组织炎症和细菌感染相关的事件。从以前的工作中采用钛的阳极氧化到发射纳米管结构的鲜明，我们利用这种技术创造了一种纳米末期表面，其表现为非侵蚀药物洗脱模板，用于延长万古霉素的模型抗生素。作为概念证据，我们使用壳聚糖 - 聚（乙二醇）（PEG）涂层，以提供储存在纳米孔的下面的三维网络中的Vancomycin分子的pH依赖性释放动力学。通过ATR-FTIR和DPFM-AFM的聚合物混合物的物理化学表征推出其形态学和纳米机械特性，并允许将它们与三种不同PH的水溶液中的稳定性和肿胀行为联系起来。本研究证明了纳米钨钛表面能够提供延长的万古霉素的延长洗脱，其中最有效的抗生素抗生素，超过一周，成为现有药物洗脱金属平台的有效替代品。此外，我们的结果表明，通过利用未交联和交联的壳聚糖涂层，最终铺平越野用作纳米多孔的多功能涂层，可以调节洗脱轮廓如何响应周围环境的酸化。药物交付平台。

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  • 来源
    《RSC Advances》 |2015年第113期|共10页
  • 作者

    Amrani Selya; Atwal Aman; Variola Fabio;

  • 作者单位

    Univ Ottawa Dept Mech Engn Ottawa ON K1N 6N5 Canada;

    Univ Ottawa Dept Mech Engn Ottawa ON K1N 6N5 Canada;

    Univ Ottawa Dept Mech Engn Ottawa ON K1N 6N5 Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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