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Review: unraveling the less explored flocking technology for tissue engineering scaffolds

机译：点评：解开组织工程脚手架的较少探索的植绒技术

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摘要

Clinical translation of the scaffold-based tissue engineering (TE) therapy still faces a multitude challenges despite intense investigations and advancement over the years. In order to circumvent clinical barriers, it is important to analyze the current technical challenges in constructing a clinically efficacious scaffold and subsequent issues relating to tissue repair. The major limitations of the current scaffolds are lack of sufficient vascularisation, mechanical strength and issues related to the osseointegration of the scaffold in the case of bone tissue engineering. Hence, this review accentuates the main challenges hampering widespread clinical translation of scaffold-based TE, with a focus on novel scaffolds fabricated using flocking technology. Flock technology is a well known method used in the textile industry. Flocking applications for scaffold fabrication are less explored, yet they offer promising solutions for creating anisotropic scaffolds with high compressive strength despite their high porosity. Critical insights into the current research on fabricated flock scaffold and future directions for advancing flocking to nextgeneration TE scaffolds into the clinical realm are discussed. This review will serve as a comprehensive reference for understanding the vital pre-requisite properties of scaffolds, and the principles and factors governing the flocking of scaffolds and the improved properties of flock scaffolds. Further, this will promote flocking technology as a plausible candidate to spearhead TE scaffold fabrication.
机译：尽管多年来强烈的调查和进步，但基于脚手架的组织工程（TE）疗法的临床翻译仍然面临着多种挑战。为了规避临床障碍，重要的是分析当前的技术挑战，在构建临床有效的支架和与组织修复有关的随后问题。在骨组织工程的情况下，当前支架的主要限制缺乏足够的血管和与支架的骨整合有关的血管和问题。因此，本综述强调了妨碍了基于脚手架的临床翻译的主要挑战，专注于使用植绒技术制造的新型支架。植物技术是纺织业中使用的众所周知的方法。支架制造的植绒应用较少探索，但它们提供了有希望的解决方案，尽管它们具有高孔隙率，但仍然具有高抗压强度的各向异性支架。讨论了对植物脚手架的当前研究以及将植入蜂拥到NextGeneration TE支架进入临床领域的关键见解。本综述将作为理解脚手架的重要前提条件的全面参考，以及治疗脚手架植入的原则和因素以及群脚手架的改进性能。此外，这将促进植绒技术作为Spearhead Te脚手架制造的合理候选者。

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  • 来源
    《RSC Advances》 |2015年第89期|共16页
  • 作者

    Vellayappan M. V.; Jaganathan S. K.; Supriyanto E.;

  • 作者单位

    Univ Teknol Malaysia IJN UTM Cardiovasc Engn Ctr Fac Biosci &

    Med Engn Johor Baharu 81310 Malaysia;

    Univ Teknol Malaysia IJN UTM Cardiovasc Engn Ctr Fac Biosci &

    Med Engn Johor Baharu 81310 Malaysia;

    Univ Teknol Malaysia IJN UTM Cardiovasc Engn Ctr Fac Biosci &

    Med Engn Johor Baharu 81310 Malaysia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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