Asymmetric synthesis of amino-benzothiazol derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines

Dai Yanling; Xie Chen; Wu Lingmin; Mei Haibo; Soloshonok Vadim A.; Han Jianlin; Pan Yi

首页> 外文期刊>RSC Advances >Asymmetric synthesis of amino-benzothiazol derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines

【24h】

Asymmetric synthesis of amino-benzothiazol derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines

机译：通过添加2锂苯并噻唑酯至（S）-N-T-丁基磺酰基 - 酮亚胺，不对称合成氨基 - 苯并噻唑衍生物

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The reactions between lithium-benzothiazoles and (S)-N-tert-butanesulfinylketimines have been found to be of general synthetic importance for asymmetric preparation of previously unknown type of amino-benzothiazol derivatives of high pharmaceutical potential. In most cases, the reactions proceed with excellent diastereoselectivities and good isolated yields of the target compounds rendering the developed procedure of high synthetic value and immediate practical use.

机译：已经发现锂 - 苯并噻唑和（S）-N-叔丁磺基磺酰基亚胺的反应具有一般的合成重要性，用于高药物潜力的先前未知的氨基 - 苯并噻唑衍生物的不对称制剂。在大多数情况下，反应采用优异的非对映心选择性和良好的分离产量，其靶化合物提供高合成值和立即实际使用的开发程序。

著录项

来源
《RSC Advances》 |2015年第5期|共7页
作者
Dai Yanling; Xie Chen; Wu Lingmin; Mei Haibo; Soloshonok Vadim A.; Han Jianlin; Pan Yi;
展开▼
作者单位

Nanjing Univ Sch Chem &

Chem Engn State Key Lab Coordinat Chem Nanjing 210093 Jiangsu Peoples R China;

Nanjing Univ Sch Chem &

Chem Engn State Key Lab Coordinat Chem Nanjing 210093 Jiangsu Peoples R China;

Nanjing Univ Sch Chem &

Chem Engn State Key Lab Coordinat Chem Nanjing 210093 Jiangsu Peoples R China;

Nanjing Univ Sch Chem &

Chem Engn State Key Lab Coordinat Chem Nanjing 210093 Jiangsu Peoples R China;

Univ Basque Country UPV EHU Fac Chem Dept Organ Chem 1 San Sebastian 20018 Spain;

Nanjing Univ Sch Chem &

Chem Engn State Key Lab Coordinat Chem Nanjing 210093 Jiangsu Peoples R China;

Nanjing Univ Sch Chem &

Chem Engn State Key Lab Coordinat Chem Nanjing 210093 Jiangsu Peoples R China;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Asymmetric synthesis of amino-benzothiazol derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines [J] . Dai Yanling, Xie Chen, Wu Lingmin, RSC Advances . 2015,第5期

机译：通过添加2锂苯并噻唑酯至（S）-N-T-丁基磺酰基 - 酮亚胺，不对称合成氨基 - 苯并噻唑衍生物
2. A novel asymmetric indolo[3,2-b]carbazole derivative containing benzothiazole and dimesitylboron units: Synthesis, photophysical and sensing properties [J] . HepingShi, Jinwei Yang, XiuqingDong Synthetic Metals . 2013,第Null期

机译：新型的不对称吲哚并[3,2-b]咔唑衍生物，含苯并噻唑和二甲磺隆单元：合成，光物理和传感性质
3. Mannich-Type Addition Reactions between Lithium Derivatives of Benzo[d]thiazoles and N-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimine: Convenient Generalized Synthesis of Bis(benzothiazole)s [J] . Haibo Mei, Yanling Dai, Lingmin Wu, European journal of organic chemistry . 2014,第12aEP期

机译：苯并[d]噻唑锂衍生物与N-叔丁基亚磺酰基-3,3,3-三氟乙醛亚胺之间的曼尼希型加成反应：双（苯并噻唑）的常规合成
4. Michael Addition Reactions between Nucleophilic GlycineEquivalents and Acrylic Acid Derivatives as a Practicaland Generalized Approach to the Asymmetric Synthesisof II-Substituted-a-Amino Acids [C] . Vadim A. Soloshonok, Hisanori Ueki, Trevor K. Ellis ACS symposium asymmetric synthesis and application of α-amino acids . 2009

机译：亲核糖糖糖尿剂与丙烯酸衍生物之间的迈克尔添加反应作为不对称合成的不对称 - A-氨基酸的不对称方法的普遍化方法
5. Asymmetric synthesis of C-1 substituted cocaine analogues using sulfinimine (N-sulfinyl imine) chemistry and vinylaluminum addition to sulfinimines (n-sulfinyl imines) for the asymmetric synthesis of alpha-substituted-beta-amino esters. [D] . Gaddiraju, Narendra Varma. 2013

机译：不对称合成C-1取代可卡因类似物，使用亚磺胺（N-亚磺酰基亚胺）化学物质和乙烯基铝加成亚磺胺（n-亚磺酰基亚胺）进行α-取代-β-氨基酯的不对称合成。
6. Catalytic Asymmetric Synthesis of Trifluoromethylated γ-Amino Acids via Umpolung Addition of Trifluoromethyl Imines to Carboxylic Acid Derivatives [O] . Bin Hu, Li Deng -1

机译：三氟甲基亚胺在羧酸衍生物上的Umpolung加成催化合成三氟甲基化的γ-氨基酸
7. Synthesis of chiral anti-1,2-diamine derivatives through copper(I)-catalyzed asymmetric α-addition of ketimines to aldimines [O] . Xu-Cheng Gan, Cheng-Yuan Zhang, Feng Zhong, 2020

机译：通过铜（I）对手性抗1,2-二胺衍生物的合成 - 催化不对称α-加入乙腈

Asymmetric synthesis of amino-benzothiazol derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines

摘要

著录项

相似文献

相关主题

期刊订阅