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Chain length effect on drug delivery of chrysin modified mPEG-PCL micelles

机译：Chrysin改性MPEG-PCL胶束药物递送的链长效应

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摘要

Four chrysin modified mPEG-PCL block copolymers with different chain lengths of mPEG and PCL blocks were synthesized and self-assembled into micelles to load the anticancer drug doxorubicin (DOX). The effect of block chain length on drug delivery was investigated. The four block copolymers were characterized by H-1 NMR, GPC and DSC. The drug loading contents of all the micelles were higher than 20%, the mPEG2k-PCL5k-CHS micelles showed the highest drug loading content and encapsulation efficiency of 26.8% and 93%, respectively. The micelles were spherical with the size increasing after drug encapsulation, and the mean size of the drug loaded micelles was around 100 nanometers. pi-pi stacking interactions between the micelles and DOX was invoked. The mPEG2k-PCL5k-CHS micelles exhibited the best profile for sustained-release. The cellular uptake and IC50 revealed that the DOX loaded mPEG2k-PCL5k-CHS micelles showed the best anticancer activity in vitro.
机译：用不同链长的MPEG和PCL嵌段的四种蛹改性的MPEG-PCL嵌段共聚物被合成并自组装成胶束以加载抗癌药物（DOX）。 研究了块链长度对药物递送的影响。 通过H-1 NMR，GPC和DSC表征四个嵌段共聚物。 所有胶束的药物装载含量高于20％，MPEG2K-PCL5K-CHS胶束显示出最高药物负载含量和包封效率分别为26.8％和93％。 胶束是球形的，在药物包封后的尺寸增加，并且药物负载胶束的平均尺寸约为100纳米。 调用胶束和DOX之间的PI-PI堆叠相互作用。 MPEG2K-PCL5K-CHS胶束表现出最佳的持续释放型材。 蜂窝摄取和IC50揭示了DOX负载的MPEG2K-PCL5K-CHS胶束在体外显示出最佳的抗癌活性。

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  • 来源
    《RSC Advances》 |2015年第73期|共8页
  • 作者

    Liang Yan; Peng Xinyu; Chen Ying; Deng Xin; Gao Wenxia; Cao Jun; Chang Jing; Gu Zhongwei; He Bin;

  • 作者单位

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China;

    Ocean Univ China Coll Marine Life Sci Qingdao 266003 Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China;

    Sichuan Univ Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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