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首页> 外文期刊>Acta biomaterialia >A novel nanostructured poly(lactic-co-glycolic-acid)-multi-walled carbon nanotube composite for blood-contacting applications: thrombogenicity studies.
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A novel nanostructured poly(lactic-co-glycolic-acid)-multi-walled carbon nanotube composite for blood-contacting applications: thrombogenicity studies.

机译：用于血液接触应用的新型纳米结构聚乳酸-乙醇酸-多壁碳纳米管复合材料：血栓形成研究。

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摘要

Composite films of poly(lactic-co-glycolic-acid) with multi-walled carbon nanotubes (PLGA-MWCNT) having two different nanotube orientations, namely random and vertically aligned, have been fabricated and characterized. The effect of these nanostructured surfaces on platelet adhesion is evaluated. In particular, the thrombogenicity of the nanostructured composite films is compared with that of pristine graphite (a low thrombogenic material) and PLGA film, in order to determine the influence of surface chemistry and topography on platelet adhesion. The results in this study show that the PLGA-MWCNT composite with vertically aligned nanotubes exhibits very low levels of fibrinogen adsorption and platelet adhesion, which can be attributed to both chemical and topographical effects. Platelet adhesion shows a good correlation with the presence of COOH groups and appears to be sensitive to the topographic features of the composite films. The results in this study suggest that in addition to chemistry, nanotopographical surface modifications could be an effective strategy in the development of low thrombogenic and hemocompatible materials.
机译：制备并表征了聚乳酸-乙醇酸共聚物与多壁碳纳米管（PLGA-MWCNT）的复合膜，该复合壁具有两种不同的纳米管取向，即无规和垂直排列。评估了这些纳米结构表面对血小板粘附的影响。特别地，将纳米结构复合膜的血栓形成性与原始石墨（低血栓形成材料）和PLGA膜的血栓形成性进行比较，以确定表面化学和形貌对血小板粘附的影响。这项研究的结果表明，具有垂直排列的纳米管的PLGA-MWCNT复合材料显示出极低的纤维蛋白原吸附和血小板粘附水平，这既可以归因于化学作用，也可以归因于形貌影响。血小板粘附表现出与COOH基团的存在良好的相关性，并且似乎对复合膜的形貌特征敏感。这项研究的结果表明，除了化学以外，纳米形貌的表面修饰可能是开发低血栓形成和血液相容性材料的有效策略。

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