Synthesis, characterization and drug release studies of poly(2-hydroxyethyl methacrylate)/KIT-5 nanocomposite as an innovative organic-inorganic hybrid carrier system

Kalbasi Roozbeh Javad; Zirakbash Ali

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Synthesis, characterization and drug release studies of poly(2-hydroxyethyl methacrylate)/KIT-5 nanocomposite as an innovative organic-inorganic hybrid carrier system

机译：聚（2-羟乙基甲基丙烯酸甲酯）/试剂盒-5纳米复合材料作为创新有机无机杂交载体系统的合成，表征和药物释放研究

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Poly(2-hydroxyethyl methacrylate)/KIT-5 as an ordered mesoporous polymer-silica nanocomposite was synthesized through in situ polymerization. The chemical and physical properties of the nanocomposite were analyzed using a series of different techniques, including XRD, BET, FT-IR, SEM and TEM analysis. Afterward, this innovative ordered mesoporous nanocomposite was utilized for the delivery and controlled release of the model drug ibuprofen. In addition, the in vitro cytotoxicity of the nanocomposite was assessed by MTT assay. Overall, the results were indicative of the potential of the nanocomposite as an excellent carrier system.

机译：通过原位聚合合成聚（2-羟乙基甲基丙烯酸酯）/试剂盒-5作为有序的介孔聚合物 - 二氧化硅纳米复合材料。使用一系列不同的技术分析纳米复合材料的化学和物理性质，包括XRD，BET，FT-IR，SEM和TEM分析。之后，这种创新的有序的介孔纳米复合材料用于模型药物布洛芬的递送和控制释放。此外，通过MTT测定评估纳米复合材料的体外细胞毒性。总体而言，结果表明纳米复合材料的潜力为优异的载体系统。

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来源
《RSC Advances》 |2015年第16期|共9页
作者
Kalbasi Roozbeh Javad; Zirakbash Ali;
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Kharazmi Univ Fac Chem Tehran Iran;

Islamic Azad Univ Shahreza Branch Dept Chem Esfahan 31186145 Iran;

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正文语种 eng
中图分类化学;
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1. Synthesis, characterization and drug release studies of poly(2-hydroxyethyl methacrylate)/KIT-5 nanocomposite as an innovative organic-inorganic hybrid carrier system [J] . Kalbasi Roozbeh Javad, Zirakbash Ali RSC Advances . 2015,第16期

机译：聚（2-羟乙基甲基丙烯酸甲酯）/试剂盒-5纳米复合材料作为创新有机无机杂交载体系统的合成，表征和药物释放研究
2. Synthesis and evaluation of chitosan-graft-poly (2-hydroxyethyl methacrylate-co-itaconic acid) as a drug carrier for controlled release of tramadol hydrochloride [J] . Kaliappa gounder Subramanian, Vediappan Vijayakumar Saudi Pharmaceutical Journal . 2012,第3期

机译：壳聚糖-接枝-聚（甲基丙烯酸2-羟乙酯-衣康酸）药物的合成及评价，用于盐酸曲马多的控释
3. Complex amorphous solid dispersions based on poly(2-hydroxyethyl methacrylate): Study of drug release from a hydrophilic insoluble polymeric carrier in the presence and absence of a porosity increasing agent [J] . Everaerts Melissa, Van den Mooter Guy International Journal of Pharmaceutics . 2019,第期

机译：基于聚（2-羟乙基甲基丙烯酸甲酯）的复合无定形固体分散体：在孔隙率增加剂的存在和不存在下，从亲水性不溶性聚合物载体中的药物释放研究
4. Preparation and Drug Release Studies of Chitosan/Methoxy Poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) Nanocomposite Films for Use as Controlled Release Drug Delivery [C] . N. Niamsa, M. Srisa-ard, Y. Srisuwan, International Conference on Smart Materials - Smart/Intelligent Materials and Nanotechnology . 2008

机译：壳聚糖/甲氧基聚（乙二醇）-B-聚（D，L-丙交酯 - 共乙醇酰基）纳米复合材料用作控释药物递送的制备和药物释放研究
5. The physical and spectroscopic study of a series of poly(3-hexyl thiophene) homopolymers and poly(3-hexyl thiophene)-block-poly(2-hydroxyethyl methacrylate) diblock copolymers. [D] . Peng, Qiliang. 2010

机译：一系列聚（3-己基噻吩）均聚物和聚（3-己基噻吩）-嵌段-聚（甲基丙烯酸2-羟乙酯）二嵌段共聚物的物理和光谱研究。
6. Synthesis and evaluation of chitosan-graft-poly (2-hydroxyethyl methacrylate-co-itaconic acid) as a drug carrier for controlled release of tramadol hydrochloride [O] . Kaliappa gounder Subramanian, Vediappan Vijayakumar 2012

机译：壳聚糖-接枝-聚（甲基丙烯酸2-羟乙酯-衣康酸）药物的合成及评价用于盐酸曲马多的控释
7. Synthesis and evaluation of chitosan-graft-poly (2-hydroxyethyl methacrylate-co-itaconic acid) as a drug carrier for controlled release of tramadol hydrochloride [O] . Subramanian Kaliappa gounder, Vijayakumar Vediappan 2012

机译：壳聚糖-接枝聚甲基丙烯酸2-羟乙酯-衣康酸作为药物载体的合成及评价

Synthesis, characterization and drug release studies of poly(2-hydroxyethyl methacrylate)/KIT-5 nanocomposite as an innovative organic-inorganic hybrid carrier system

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