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Synthesis, crystal structure and biological properties of a bismuth(III) Schiff-base complex

机译：铋（III）席夫碱基复合物的合成，晶体结构和生物学性质

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摘要

In this paper, a new bismuth(III) Schiff-base complex [Bi9O8(vanen)3(NO3)2(CH3OH)2(H2O)]·3NO3·5.5H2O was synthesized by reaction of [H2vanen =N,N'-ethylene bis(3-methoxysalicylideneimine)] and Bi(NO3)3·5H2O in methanol at 45-60 °C. The inhibitory effects of the complex and its ligand on Schizosaccharomyces pombe (S. pombe) growth were investigated by microcalorimetry. The experimental results indicated the complex had a stronger inhibitory activity towards S. pombe than that of the ligand. The interaction between bovine serum albumin (BSA) and the complex under physiological conditions was studied by fluorescence spectroscopy. The complex had a quite strong ability to quench the fluorescence of BSA and their combination reactions were a static quenching process. The complex could bind BSA via a binding site and the binding distance r was 3.52 nm. The synchronous fluorescence spectroscopy further revealed that the complex had partly inserted into the hydrophobic pocket of BSA.
机译：在本文中，通过[H 2Vanen = N，N'-的反应，合成了一种新的铋（III）Schiff基复合物[Bi9O8（VANEN）3（NO 3）2（NO 3）2（NO 3）2（H 2 O）]·3·3·5 .5H2O 在45-60℃下甲醇中乙烯双（3-甲氧基钠亚二嗪）]和BI（NO3）3·5H2O。 通过微离核法研究了复合物及其配体对Schizosaccharomyces Pombe（S.Pombe）生长的抑制作用。 实验结果表明，该复合物对S.Pombe的抑制活性较强而不是配体的抑制活性。 通过荧光光谱研究了牛血清白蛋白（BSA）与生理条件下的复合物之间的相互作用。 该复合物具有相当强的淬火BSA荧光的能力，它们的组合反应是静态猝灭过程。 复合物可以通过结合位点结合BSA，结合距离R为3.52nm。 同步荧光光谱进一步揭示了该复合物已部分插入BSA的疏水袋中。

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  • 来源
    《RSC Advances》 |2015年第114期|共9页
  • 作者

    Chuan-Hua Li; Jian-Hong Jiang; Xu Li;

  • 作者单位

    Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds and Applications Department of Chemistry and Life Science Xiangnan University Chenzhou 423000 Hunan Province PR China;

    Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds and Applications Department of Chemistry and Life Science Xiangnan University Chenzhou 423000 Hunan Province PR China;

    Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds and Applications Department of Chemistry and Life Science Xiangnan University Chenzhou 423000 Hunan Province PR China;

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  • 正文语种 eng
  • 中图分类 化学;
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