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首页> 外文期刊>RSC Advances >Enhanced antibacterial activity of new 'composite' biocides with both N-chloramine and quaternary ammonium moieties
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Enhanced antibacterial activity of new 'composite' biocides with both N-chloramine and quaternary ammonium moieties

机译：用N-氯胺和季铵部分增强新“复合”杀生物剂的抗菌活性

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摘要

In view of the emerging resistance in bacteria against biocides, this work describes a novel combination of two existing biocides in one molecule to improve the bactericidal activity and overcome bacterial resistance. A new series of “composite” biocides combining an amide based N-chloramine with a quaternary ammonium (QA) moiety in one molecule was synthesized and the antibacterial kinetics of each biocide was tested against two clinically retrieved bacteria: methicillin-resistant S. aureus (MRSA) and multi-drug resistant (MDR) P. aeruginosa. The addition of multiple cationic centers into one N- chloramine molecule did not result in enhanced inactivation of bacteria. The bactericidal activity against both microbes increased dramatically when the length of the alkyl chain of QA moiety in these biocides increased to 12 and 14. Covalently bonding N-chloramine with long-chained QA moieties did result in faster kill of MRSA and MDR P. aeruginosa than the formulation with two separate counterparts (N- chloramine and long-chained QA salts). Uptake isotherm curves of the “composite” biocides with long alkyl chain substitution revealed more uptakes of the “composite” biocides by bacteria than the precursor mono-functional biocides (with only QA moieties). An improved antibacterial activity resulted from covalently bonding the two biocides (N-chloramine and long-chained QA salts) into one molecule.
机译：鉴于对杀生物剂的细菌的出现抗性，这项工作描述了一种分子中的两种现有杀生物剂的新组合，以改善杀菌活性并克服细菌抗性。合成了一种新的“复合”杀生物剂，将基于酰胺的N-氯胺与一个分子中的季铵（QA）部分组合，并对每种杀生物剂的抗菌动力学进行测试，对两种临床检索的细菌进行测试：耐甲氧脲耐金黄色葡萄球菌（ MRSA）和多药物耐药（MDR）P. Aeruginosa。将多个阳离子中心添加到一个N氯胺分子中并未导致细菌的增强灭活。当这些杀生物剂中的QA部分的烷基链的长度增加至12和14时，抗两种微生物的杀菌活性显着增加。与长链QA部分共价键合N-氯胺确实导致MRSA和MDR P. Aeruginosa更快地杀死比用两种单独的对应物（N-氯胺和长链QA盐）制剂。具有长烷基链取代的“复合材料”生物剂的摄取等温曲线揭示了比前体单官能杀菌剂（仅QA部分）的“复合材料”杀生物剂的更多上升剂。将两种杀生物剂（N-氯胺和长链QA盐）共价键合成一个分子，得到改善的抗菌活性。

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  • 来源
    《RSC Advances》 |2015年第114期|共11页
  • 作者

    Chenxi Ning; Lingdong Li; Sarvesh Logsetty;

  • 作者单位

    Department of Textile Sciences Faculty of Human Ecology University of Manitoba Winnipeg Canada R3T 2N2.;

    School of Petroleum &

    Chemical Engineering Dalian University of Technology (Panjin Campus) No.2 Dagong Road Liaodongwan New District Panjin PR China 124221;

    Manitoba Firefighters Burn Unit Department of Surgery Faculty of Medicine University of Manitoba Winnipeg Canada R3A 1R9;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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