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首页> 外文期刊>RSC Advances >Flexible PEGDA-based microneedle patches with detachable PVP-CD arrowheads for transdermal drug delivery
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Flexible PEGDA-based microneedle patches with detachable PVP-CD arrowheads for transdermal drug delivery

机译：基于PEGDA的柔性微针贴片，具有可拆卸PVP-CD箭头，用于透皮药物输送

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摘要

Traditional drug administration using hypodermic needles not only causes severe pain and bleeding to the patients, but also requires professional operation by trained healthcare practitioners. Recently, various types of microneedle patches have been developed for pain-free subcutaneous delivery of drugs and vaccines. However, for most existing microneedle devices, the backing layer where the microneedles grow remains attached to the skin until complete release of the drug. In this work, a novel microneedle patch is designed and fabricated by assembling drug-loaded polyvinylpyrrolidone-cyclodextrin (PVP-CD) arrowheads that are detachable from polyethylene glycol diacrylate (PEGDA)-based needle shafts. When applying this patch onto the skin, the drug-loaded polymer arrowheads with sharp tips can effectively penetrate through the epidermis. Then the backing substrate with blunt PEGDA shafts can be peeled off and discarded shortly after administration, while the drug-loaded polymer arrowheads remain embedded in the dermis for further dissolution and drug release. This simple and convenient drug administration using detachable microneedle patches is very user-friendly and also can effectively address the cosmetic concerns of the patients. Additionally, this patch device features a flexible substrate and thus can adhere to the lesion surface with any curvature. The drug delivery based on this versatile microneedle patch is expected to create new therapeutic modalities for treating various local and systemic diseases with the advantages of convenience, safety and self-administration.
机译：使用皮下注射针的传统药物管理不仅会导致严重的疼痛和患者出血，而且还需要经过培训的医疗从业者的专业操作。最近，已经开发了各种类型的微针斑块用于免疫皮下递送药物和疫苗。然而，对于大多数现有的微针装置，微针生长的背衬层保持粘附到皮肤上，直至完全释放药物。在这项工作中，通过组装含药的聚乙烯吡咯烷酮 - 环糊精（PVP-CD）箭头设计和制造新的微针贴片，该箭头被从聚乙二醇二丙烯酸酯（PEGDA）的针轴上脱离。当将该贴片施加到皮肤上时，具有尖锐尖端的药物装载的聚合物箭头可以有效地穿过表皮渗透。然后，具有钝器轴的背衬基板可以剥离并在给药后不久丢弃，而药物负载的聚合物箭头仍然嵌入皮革中，以进一步溶解和药物释放。这种简单方便的药物管理局使用可拆卸的微针贴片是非常用户友好的，也可以有效地解决患者的化妆品问题。另外，该贴片装置具有柔性基板，因此可以粘附到具有任何曲率的病变表面。预计基于该通用微针贴片的药物递送将为治疗各种局部和全身疾病具有方便，安全性和自我管理的优点来产生新的治疗方式。

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  • 来源
    《RSC Advances》 |2015年第92期|共6页
  • 作者

    Xue Peng; Zhang Xuyang; Chuah Yon Jin; Wu Yafeng; Kang Yuejun;

  • 作者单位

    Nanyang Technol Univ Sch Chem &

    Biomed Engn Singapore 637459 Singapore;

    Nanyang Technol Univ Sch Chem &

    Biomed Engn Singapore 637459 Singapore;

    Nanyang Technol Univ Sch Chem &

    Biomed Engn Singapore 637459 Singapore;

    Nanyang Technol Univ Sch Chem &

    Biomed Engn Singapore 637459 Singapore;

    Nanyang Technol Univ Sch Chem &

    Biomed Engn Singapore 637459 Singapore;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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