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首页> 外文期刊>RSC Advances >Stability and controlled antibiotic release from thin films embedded with antibiotic loaded mesoporous silica nanoparticles
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Stability and controlled antibiotic release from thin films embedded with antibiotic loaded mesoporous silica nanoparticles

机译：从嵌入抗生素负载的中孔二氧化硅纳米粒子的薄膜中稳定性和受控抗生素释放

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摘要

Herein we report the preparation of antibiotic thin film coatings with excellent stability and well-regulated drug release profile. These films were prepared by pre-loading of the antibiotic gentamicin into mesoporous silica nanoparticles (MSN-G) to form drug nanoreservoirs, which were then coated onto glass substrates followed by adding a polymer (Nafion) protecting layer. Fourier transform infrared (FTIR) spectroscopy and scanning electronic microscopy (SEM) confirmed the successful coating of MSN-G particles on slides. Factors such as the thickness and number of Nafion layers, the thickness of the MSN-G layer, as well as the pH of the surrounding medium were found to affect the stability of the films in solution. A typical film with 7.5 mg MSN-G particles and a thin layer of Nafion coating remained intact more than 80 days in a pH 7.4 simulated body fluid at 37 degrees C, which is highly promising for further biomedical application. The loaded gentamicin was found to be slowly released from thin films and the release profile could be tuned by varying the pH of the release media. For example, a steady and sustained release of gentamicin (total 95% of the loading amount) was achieved over up to 38 days in a mildly acidic solution (pH 5.5) or 56 days at the physiologic condition (pH 7.4). These films with outstanding stability and controlled release profile are expected to find promising applications in many fields, such as antibiotic coatings for biomedical devices.
机译：在此，我们报告了具有优异稳定性和稳定的药物释放曲线的抗生素薄膜涂层的制备。这些薄膜通过将抗生素庆大霉素预加载到介孔二氧化硅纳米粒子（MSN-G）中来制备，以形成药物纳米硼，然后将其涂覆到玻璃基板上，然后加入聚合物（Nafion）保护层。傅里叶变换红外（FTIR）光谱和扫描电子显微镜（SEM）证实了载玻片上的MSN-G颗粒的成功涂覆。发现诸如Nafion层的厚度和数量，MSN-G层的厚度以及周围培养基的pH的因素，以影响溶液中膜的稳定性。具有7.5mg MSN-G颗粒的典型薄膜和薄层的Nafion涂层在pH 7.4模拟体液中以37摄氏度保持超过80天，这对于进一步的生物医学应用具有高度前途。发现负载的庆大霉素从薄膜缓慢释放，通过改变释放介质的pH可以调节释放曲线。例如，在生理病症（pH7.4）的温和酸性溶液（pH 5.5）或56天内，在温和酸性溶液（pH 5.5）中稳定和持续释放的庆大霉素（总量95％的负载量）。这些薄膜具有出色的稳定性和控制释放曲线，可以在许多领域中找到有前途的应用，例如生物医学装置的抗生素涂层。

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  • 来源
    《RSC Advances》 |2015年第130期|共8页
  • 作者

    Tamanna Tasnuva; Bulitta Jurgen B.; Landersdorfer Cornelia B.; Cashin Veronica; Yu Aimin;

  • 作者单位

    Swinburne Univ Technol Fac Sci Engn &

    Technol Hawthorn Vic 3122 Australia;

    Univ Florida Coll Pharm Ctr Pharmacometr &

    Syst Pharmacol Gainesville FL 32611 USA;

    Monash Univ Monash Inst Pharmaceut Sci Drug Delivery Disposit &

    Dynam Clayton Vic 3800 Australia;

    Swinburne Univ Technol Fac Sci Engn &

    Technol Hawthorn Vic 3122 Australia;

    Swinburne Univ Technol Fac Sci Engn &

    Technol Hawthorn Vic 3122 Australia;

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  • 正文语种 eng
  • 中图分类 化学;
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