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Bioactive Ti alloy with hydrophilicity, antibacterial activity and cytocompatibility

机译：具有亲水性，抗菌活性和细胞偶联性的生物活性Ti合金

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摘要

Titanium-6 aluminium-4 vanadium (Ti64) alloy was modified to a hydrophilic, cytocompatible, antibacterial and bioactive surface via a simple cost effective chemical treatment method. A fine porous network structure of sodium hydrogen titanate (SHT) was formed on the Ti64 alloy surface by using sodium hydroxide treatment. The incorporated Na+ ions are replaced by Ag+ ions by a subsequent silver nitrate treatment. Contact angle measurement indicated that the silver containing Ti64 alloy surface is hydrophilic at lower silver concentration. The antibacterial study of the thus prepared sample against Staphylococcus aureus confirmed the bacterial resistance of the Ti64 alloy. As evident from the AAS result, the sustained release of Ag into the culture medium results in antibacterial activity. Cytocompatibility studies on MG63 cell lines showed above 80% cell viability and also good cell attachment. This confirmed the nontoxic behavior of the present optimized silver concentration on the Ti64 surface for MG63 cells. In vitro bioactivity of the silver containing Ti64 sample in simulated body fluid showed bone-like apatite formation and the apatite-forming ability is not affected by Ag concentration or by heat treatment. Taken together, this surface modification study adds further information to our knowledge on the development of a bioactive Ti64 alloy with hydrophilicity, antibacterial activity and biocompatibility that may have considerable potential application as orthopedic and dental implants.
机译：通过简单的成本有效的化学处理方法，将钛-6铝-4钒（Ti64）合金改性为亲水性，细胞势抗体，抗菌和生物活性表面。通过使用氢氧化钠处理在Ti64合金表面上形成钛酸钠（SHT）的精细多孔网络结构。将掺入的Na +离子通过随后的硝酸银处理来取代Ag +离子。接触角测量表明，含有Ti64合金表面的银在较低的银浓度下是亲水性的。对如此制备的样品对金黄色葡萄球菌的抗菌研究证实了Ti64合金的细菌抗性。从AAS结果中显而易见，Ag的持续释放到培养基中导致抗菌活性。对Mg63细胞系的细胞偶联性研究显示出高于80％的细胞活力和良好的细胞附着。这证实了用于Mg63细胞的Ti64表面上存在的本优化银浓度的无毒行为。在模拟体液中含有Ti6 4样品的银的体外生物活性显示出骨状磷灰石形成，并且磷灰石形成能力不受Ag浓度或通过热处理的影响。在一起，这种表面改性研究进一步了解我们对具有亲水性，抗菌活性和生物相容性的生物活性Ti64合金的知识，这可能具有可具有相当大的潜在应用作为整形外科和牙科植入物的生物活性，抗菌活性和生物相容性。

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  • 来源
    《RSC Advances》 |2015年第63期|共11页
  • 作者

    Prabu Vinod; Karthick P.; Rajendran Archana; Natarajan Duraipandy; Kiran M. S.; Pattanayak Deepak K.;

  • 作者单位

    CSIR Cent Electrochem Res Inst Karaikkudi 630006 Tamil Nadu India;

    CSIR Cent Electrochem Res Inst Karaikkudi 630006 Tamil Nadu India;

    CSIR Cent Electrochem Res Inst Karaikkudi 630006 Tamil Nadu India;

    CSIR Cent Leather Res Inst Chennai 600020 Tamil Nadu India;

    CSIR Cent Leather Res Inst Chennai 600020 Tamil Nadu India;

    CSIR Cent Electrochem Res Inst Karaikkudi 630006 Tamil Nadu India;

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  • 正文语种 eng
  • 中图分类 化学;
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