• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Tissue paper assisted spray ionization mass spectrometry
【24h】

Tissue paper assisted spray ionization mass spectrometry

机译：薄纸辅助喷射电离质谱

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Electrospray ionization mass spectrometry (ESI-MS) has been widely utilized in the analysis of analytes with a wide mass range. A metal ESI emitter, which is usually applied with a high voltage, is required in the setup of ESI-MS. Nevertheless, electrospray can be induced simply by the electric field provided by the mass spectrometer without applying electric contact on the ESI emitter. In this work, we demonstrate a simple and straightforward ionization technique for MS analysis by utilizing tissue paper as the sampling substrate and the ESI emitter. The fine fibers on the paper can work as ESI-like emitters to facilitate the generation of electrospray. When a small piece of tissue paper (diameter: ～4 mm) loaded with a few microliters of the sample solu- tion was positioned in the proximity of the inlet of a mass spectrom- eter applied with a high voltage, the analyte ions were readily generated and obtained by the mass spectrometer. Although no electric contact was made on the paper, the high voltage applied at the inlet of the mass spectrometer induced the formation of elec- trospray for MS analysis. This approach is applicable to the analysis of various samples including organic compounds, peptides, proteins, and complex samples. Additionally, tissue paper is flexible and can be used to sample trace amounts of samples fromsurface of solid objects such as drug tablets simply through wiping. The tissue with a trace amount of samples then can be readily placed close in front of the inlet ofmass spectrometer followed by solvent deposition for MS analysis. Addi- tionally, we also examined the feasibility of using this approach for quantitative MS analysis.
机译：电喷雾电离质谱（ESI-MS）已被广泛地用于分析物具有宽质量范围的分析。金属ESI发射器，其通常用高电压施加，需要在ESI-MS的设置。尽管如此，电可简单地通过不施加在发射极ESI电接触由质谱仪提供的电场诱导。在这项工作中，我们通过利用薄纸作为取样基板和所述发射极ESI用于演示MS分析简单而直接的电离技术。纸上的细纤维可以作为ESI般的发射器，以方便电的产生。当薄纸的一小片：装载有样品solu-和灰的几微升（直径约4毫米）放置在一团spectrom- ETER的入口附近具有高电压施加时，分析物离子被容易地生成并且由质谱仪获得。虽然没有电接触是在纸张制造，高电压施加在感应电喷雾的用于MS分析形成的质谱仪的入口。这种方法适用于各种样品，包括有机化合物，肽，蛋白质，和复杂样品的分析。此外，纸巾是柔性的并且可用于样品的痕量固体对象的样品fromsurface的如药物片剂通过简单地擦拭。然后与样品的微量该组织可以在入口的前面容易地放置在靠近ofmass分光计然后进行溶剂沉积用于MS分析。再者，将我们还研究了使用这种方法的定量质谱分析的可行性。

著录项

  • 来源
    《RSC Advances》 |2015年第114期|共6页
  • 作者

    Anil Kumar Meher; Yu-Chie Chen;

  • 作者单位

    Department of Applied Chemistry National Chiao Tung University Hsinchu 300 Taiwan.;

    Department of Applied Chemistry National Chiao Tung University Hsinchu 300 Taiwan.;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号