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首页> 外文期刊>Acta Dermato-Venereologica >Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy.
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Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy.

机译：痤疮的病理机制特别是痤疮丙酸杆菌及其相关治疗。

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Acne is a common disease that in cases of extreme disfiguration can have severe consequences for the personality development of young people and is associated with a relatively high prevalence of depression and suicide. Spontaneous regression is common, but acne can extend into the fourth and fifth decades of life. The pathogenesis is still not fully understood. Factors promoting the development of acne are: increased sebum production, ductal cornification, bacterial colonization of the pilosebaceus ducts and inflammation. However, there is evidence that inflammation is not a factor but rather a consequence of the interaction of the other three factors. Propionibacterium acnes releases pro-inflammatory cytokines as well as antigens and mitogen(s), with cellular and non-cellular responses to these products triggering inflammation. Treatment is often frustran. Therapeutical strategies are needed based on new understandings of the pathomechanisms involved in acne. The aim of this review is to summarize the data on aetiopathological factors in acne and their contribution to acne pathology and therapy.
机译：痤疮是一种常见疾病，在极度变容的情况下，可能对年轻人的人格发展产生严重影响，并与抑郁症和自杀率较高相关。自发性消退很普遍，但痤疮可以延续到生命的第四和第五个十年。发病机理仍未完全了解。促进痤疮发展的因素有：皮脂分泌增加，导管角质化，pilosebaceus导管细菌定植和炎症。但是，有证据表明炎症不是其他因素，而是其他三个因素相互作用的结果。痤疮丙酸杆菌释放促炎细胞因子以及抗原和促有丝分裂原，对这些产物的细胞和非细胞反应引发炎症。治疗通常是挫败感。根据对痤疮涉及的发病机理的新认识，需要治疗策略。这篇综述的目的是总结关于痤疮的病理因素及其对痤疮病理学和治疗的贡献的数据。

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