• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation.
【24h】

Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation.

机译：低度纤维瘤样肉瘤：细针穿刺细胞学检查和组织学相关性病例报告。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Low grade fibromyxoid sarcoma has been fully described histologically; however, the fine needle aspiration (FNA) cytologic findings are scantily defined, and the distinction from other benign and malignant soft tissue tumors can be difficult. CASE: We examined FNA cytologic material from a slowly growing, large chest wall mass in a 28-year-old woman. The surgical specimen was processed for routine histology and immunohistochemical studies. The cytologic smears were adequately cellular, showing spindly cells with uniform, elongated nuclei; small, inconspicuous nucleoli; and scanty, wispy cytoplasm associated with myxoid material. No significant nuclear pleomorphism or mitoses were noted. The excised tumor was well circumscribed, focally infiltrating the surrounding muscles. The cut surface was variable, featuring fibrous, solid, fleshy and myxoid areas. Microscopically, the solid, fibrous areas displayed increased cellularity with storiform, intersecting and parallel patterns. In the myxoid areas the cells grew in a haphazard fashion and appeared floating in abundant mucoid matrix associated with a capillary vascular network similar to the chicken-wire pattern seen in cases of myxoid liposarcoma. The tumor cells were spindly, with fusiform, uniform nuclei. Focal, moderate nuclear pleomorphism was noted. The mitotic index was low. The tumor cells were positive for vimentin, alpha-1-antitrypsin and lysozyme and negative for S-100, actin, desmin and CD34. CONCLUSION: Although low grade fibromyxoid sarcoma is a rare neoplasm, it should be recognized and distinguished from other soft tissue tumors because of its low malignant potential. The definitive FNA cytologic diagnosis can be challenging but is possible if the tumor is adequately sampled, with multiple passes from different areas. Clinical and radiologic correlations are of great help. All spindle cell tumors with myxoid changes, such as myxoid liposarcoma, myxofibrosarcoma, cellular myxoma, myxoid leiomyosarcoma and peripheral nerve sheath tumors, should be considered in the differential diagnosis. In contrast to the cytologic features, the histologic findings are characteristic and well established.
机译：背景：组织学已充分描述了低度纤维肉瘤样肉瘤。然而，细针穿刺术（FNA）的细胞学检查结果定义不清，很难与其他良性和恶性软组织肿瘤区分开。案例：我们检查了一名28岁女性的缓慢增长的大胸壁肿块的FNA细胞学物质。对手术标本进行常规组织学和免疫组织化学研究。细胞学涂片具有足够的细胞性，显示出具有均匀，细长核的刺状细胞。小而不起眼的核仁;与黏液状物质相关的稀疏，稀疏的细胞质。没有发现明显的核多态性或有丝分裂。切除的肿瘤界限清楚，局部浸润周围的肌肉。切面变化多端，具有纤维状，实心，肉质和粘液状区域。在显微镜下，固体纤维区域显示出蜂窝状，相交和平行模式的细胞增多。在粘液样区域中，细胞以杂乱无章的方式生长，并出现在与毛细血管网络相关的丰富的粘液样基质中漂浮，类似于在粘液样脂肪肉瘤病例中看到的鸡丝模式。肿瘤细胞呈梭形，纺锤形，核均一。注意到局灶性，中度核多态性。有丝分裂指数低。肿瘤细胞中波形蛋白，α-1-抗胰蛋白酶和溶菌酶呈阳性，而S-100，肌动蛋白，结蛋白和CD34呈阴性。结论：尽管低度纤维瘤样肉瘤是一种罕见的肿瘤，但由于其低恶性潜能，因此应与其他软组织肿瘤相区别。明确的FNA细胞学诊断可能具有挑战性，但如果对肿瘤进行充分取样且来自不同区域的多次检查，则可能是可行的。临床和放射学相关性有很大帮助。在鉴别诊断中，应考虑所有具有粘液样改变的梭形细胞肿瘤，例如粘液样脂肪肉瘤，粘液原纤维肉瘤，细胞粘液瘤，粘液样平滑肌肉肉瘤和周围神经鞘瘤。与细胞学特征相反，组织学发现是特征性的并且已经建立。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号