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首页> 外文期刊>Acta crystallographica, Section F. Structural biology and crystallization communications >Crystallization and preliminary X-ray crystallographic analysis of the rhesus macaque MHC class I molecule Mamu-B*17 complexed with an immunodominant SIVmac239 Env epitope
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Crystallization and preliminary X-ray crystallographic analysis of the rhesus macaque MHC class I molecule Mamu-B*17 complexed with an immunodominant SIVmac239 Env epitope

机译：猕猴MHC I类分子Mamu-B * 17与免疫优势SIVmac239 Env表位复合的结晶和初步X射线晶体学分析

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摘要

Long-term nonprogression during simian immunodeficiency virus (SIV) infection has been strongly associated with the major histocompatibility complex (MHC) class I allele Mamu-B*17. Here, a complex of rhesus macaque Mamu-B*17 with rhesus macaque beta(2)-microglobulin (beta(2)m) and an immunodominant peptide (SIVmac239 Env241-251; LRCNDTNYSGF; Env LF11) derived from the SIV Env protein was crystallized by the hanging-drop method using PEG 3350 as a precipitating agent. The crystals belonged to the primitive monoclinic space group P2, with unit-cell parameters a = 68.3, b = 45.0, c = 81.5 angstrom, beta = 96.5 degrees. Assuming the presence of one molecule in the asymmetric unit, the Matthews coefficient and solvent content were calculated to be 2.96 angstrom(3)Da(-1) and 58.5%, respectively.
机译：猿猴免疫缺陷病毒（SIV）感染期间的长期不进展与主要组织相容性复合体（MHC）I类等位基因Mamu-B * 17密切相关。在这里，恒河猴猕猴B * 17与恒河猴β（2）-微球蛋白（beta（2）m）和源自SIV Env蛋白的免疫优势肽（SIVmac239 Env241-251; LRCNDTNYSGF; Env LF11）的复合物是使用PEG 3350作为沉淀剂，通过悬滴法结晶。晶体属于原始单斜空间群P2，其晶胞参数a = 68.3，b = 45.0，c = 81.5埃，β= 96.5度。假设不对称单元中存在一个分子，则马修斯系数和溶剂含量经计算分别为2.96埃（3）Da（-1）和58.5％。

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