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首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Expression of cytokeratin 19 and protein p63 in fine needle aspiration biopsy of papillary thyroid carcinoma.
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Expression of cytokeratin 19 and protein p63 in fine needle aspiration biopsy of papillary thyroid carcinoma.

机译：甲状腺乳头状癌细针穿刺活检中细胞角蛋白19和蛋白p63的表达

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OBJECTIVE: To analyze the immunocytochemical distribution of CK19 and p63 on archival cytologic smears of 27 papillary thyroid carcinomas (PTCs), 22 benign thyroid lesions and 5 malignant non-PTC lesions. STUDY DESIGN: Archival cytologic smears of 27 papillary carcinomas, 22 benign thyroid lesions and 5 malignant nonpapillary carcinomas were processed for immunocytochemical detection of CK19 and p63, and results were compared. RESULTS: CK19 showed strong cytoplasmic staining in 22/27 fine needle aspiration biopsies (FNABs) of PTCs, in 5 benign lesions and in 4 malignant lesions of the control group. p63 Positivity was present in FNABs of 20/27 PTC and in 1 FNAB of nodular hyperplasia. Eighteen FNABs of PTC (66.6%) showed both strong CK19 staining and p63-positive cells, whereas none of the control cases showed coexpression of CK19 and p63. CONCLUSION: Coexistence of strong CK19 positivity and p63-positive cells can enhance the cytologic diagnosis of PTC.
机译：目的：分析CK19和p63在27例甲状腺乳头状癌（PTC），22例甲状腺良性病变和5例恶性非PTC病变的档案细胞学涂片中的免疫细胞化学分布。研究设计：对27例乳头状癌，22例甲状腺良性病变和5例恶性非乳头状癌的存档细胞学涂片进行了CK19和p63的免疫细胞化学检测，并比较了结果。结果：在对照组的5个良性病变和4个恶性病变中，CK19在PTC的22/27细针穿刺活检组织（FNABs）中显示出强烈的细胞质染色。 p63正性存在于20/27 PTC的FNAB和1个结节性增生的FNAB中。 PTC的18个FNAB（66.6％）显示出强CK19染色和p63阳性细胞，而对照例均未显示CK19和p63的共表达。结论：强CK19阳性和p63阳性细胞并存可增强PTC的细胞学诊断。

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