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首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report.
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Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report.

机译：细针穿刺及与核心活检的相关性对下肢肺泡软组织肉瘤的细胞学诊断：病例报告。

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BACKGROUND: Alveolar soft part sarcoma is a rare soft tissue tumor of uncertain origin that is generally slow growing but unmistakably malignant due to its propensity for metastasis to lung, bone and brain early in the course of disease. Fine needle aspiration biopsy (FNAB) of these tumors and recognition of the characteristic cytologic features precludes more invasive diagnostic measures and facilitates appropriate treatment. CASE: A 54-year-old African-American man presented to our institution with a 2-week history of left leg pain. Imaging studies revealed a left leg soft tissue mass just below the popliteal fossa and multiple bilateral lung lesions suggestive of metastatic neoplasm. FNAB of the left lower extremity mass yielded uniform clusters of cells and sigle cells with large nuclei and single prominent nucleoli. Histologically, the biopsy showed nests of large polygonal cells with abundant eosinophilic cytoplasm, round regular nuclei and prominent nucleoli. A periodic acid-Schiff (PAS) stain highlighted intracytoplasmic rhomboidal crystals, a feature diagnostic of alveolar soft part sarcoma. CONCLUSION: Alveolar soft part sarcoma may be diagnosed by its unique morphologic characteristics and should be considered in the differential diagnosis of all cytologically sampled soft tissue lesions.
机译：背景：肺泡软组织肉瘤是一种罕见的，来源不明的软组织肿瘤，由于其易于在疾病过程中转移至肺，骨和脑，因此通常生长缓慢，但毫无疑问是恶性的。这些肿瘤的细针穿刺活检（FNAB）和特征性细胞学特征的识别排除了更多的侵入性诊断措施，并有助于适当的治疗。案例：一名54岁的非洲裔美国人向我们机构介绍了一个有2周左腿疼痛的病史。影像学研究发现pop腿窝下方有左腿软组织肿块，并提示有转移性肿瘤的多发性双侧肺部病变。左下肢肿块的FNAB产生均匀的细胞簇和单核细胞簇，具有大核和单个突出核仁。从组织学上看，活检显示巢状大型多角形细胞，具有丰富的嗜酸性细胞质，圆形规则核和突出的核仁。高碘酸-希夫（PAS）染色突出了胞浆内的菱形晶体，这是肺泡软部分肉瘤的特征诊断。结论：肺泡软组织肉瘤可通过其独特的形态学特征进行诊断，并应在所有细胞学取样的软组织病变的鉴别诊断中予以考虑。

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