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A versatile three-dimensional foam fabrication strategy for soft and hard tissue engineering

机译：软硬组织工程的多功能三维泡沫制造策略

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摘要

The fabrication strategies of three-dimensional porous biomaterials have been extensively studied and well established in the past few decades, yet the biocompatibility and versatility of porous architecture preparation is still lacking. Herewith, we present a novel and green 3D porous foam fabrication technique for both soft and hard engineering. By utilizing the gelatinization and retrogradation properties of starches, stabilized porous constructs made of various building blocks, from living cells to ceramic particles, were created for the first time. In soft tissue engineering applications, 3D cultured tissue foam (CTF) with controlled cell release properties was developed, and foams constituting osteoblasts, fibroblasts and vascular endothelial cells all exhibited high mechanical stability and preservation of cell viability or functions. More importantly, the CTF achieved sustained self-release of cells controlled by serum concentration (containing amylase) and the released cells also maintained high viability and functions. In the context of hard tissue engineering applications, ceramic/bioglass (BG) foam scaffolds were developed by a similar starch-assisted foaming strategy where the resultant bone scaffolds of hydroxyapatite (HA)/BGand Si3N4/BGpossessed>70% porosity with interconnected macropores (sizes 200 ~ 400 μm), fine pores (sizes 1 ~ 10 μm) and superior mechanical properties despite the high porosity. Additionally, in vitro and in vivo evaluations of the biological properties revealed that porousHA/BG foam exhibits the desired biocompatibility and osteogenesis. The in vivo study indicated new bone ingrowth after 1 week and significant increases in new bone volume after 2 weeks. In conclusion, the presented foaming strategy provides opportunities for biofabricating CTF with different cells for different target soft tissues and preparing porous ceramic/ BGfoams with different material components and high strengths, showing great versatility in soft and
机译：三维多孔生物材料的制造策略已被广泛研究，在过去几十年中已经过分了，但多孔建筑准备的生物相容性和多功能性仍然缺乏。在此，我们为软硬工程提供了一种新颖的和绿色3D多孔泡沫制造技术。通过利用淀粉的凝胶化和逆转性质，首次创建由各种建筑物块，从活细胞到陶瓷颗粒制成的稳定多孔构建体。在软组织工程应用中，开发了3D培养的组织泡沫（CTF），具有受控细胞释放性能，构成成骨细胞，成纤维细胞和血管内皮细胞的泡沫均表现出高机械稳定性和保护细胞活力或功能。更重要的是，CTF实现了由血清浓度（含淀粉酶）控制的细胞的持续自释放，并且释放的细胞也保持高可活力和功能。在坚硬的组织工程应用中，陶瓷/生物胶（BG）泡沫支架是通过类似的淀粉辅助发泡策略开发，其中羟基磷灰石（HA）/ BGANDSI3N4 / BGOSESSED的所得骨支架和孔隙率为互连的大孔（尺寸200〜400μm），细孔（尺寸1〜10μm），尽管孔隙率高，但仍有优异的机械性能。另外，体外和体内生物学的评价显示，多孔HA / BG泡沫表现出所需的生物相容性和骨质发生。体内研究表明，在1周后新的骨骼向期，2周后新骨体积的显着增加。总之，所提出的发泡策略为不同的靶软组织的不同细胞生物破坏CTF的机会，并用不同的材料成分和高强度制备多孔陶瓷/ BGFOAM，表现出柔软和柔软的多功能性

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  • 来源
    《Biomedical materials》 |2018年第2期|共12页
  • 作者

    Changlu Xu; Yanjie Bai; Shaofeng Yang; Huilin Yang; David A Stout; Phong A Tran; Lei Yang;

  • 作者单位

    College of Chemistry Chemical Engineering and Materials Science Orthopaedic Institute Soochow University Suzhou People's Republic of China;

    School of Public Health Medical College of Soochow University Suzhou Jiangsu 215123 People's Republic of China;

    Department of Orthopaedics at the First Affiliated Hospital Soochow University Suzhou Jiangsu 215006 People's Republic of China;

    Department of Orthopaedics at the First Affiliated Hospital Soochow University Suzhou Jiangsu 215006 People's Republic of China;

    International Research Centre for Translational Orthopaedics (IRCTO) and Jiangsu Key Laboratory for Carbon-Based Functional Materials&

    Devices Soochow University Suzhou Jiangsu 215006 People's Republic of China;

    International Research Centre for Translational Orthopaedics (IRCTO) and Jiangsu Key Laboratory for Carbon-Based Functional Materials&

    Devices Soochow University Suzhou Jiangsu 215006 People's Republic of China;

    College of Chemistry Chemical Engineering and Materials Science Orthopaedic Institute Soochow University Suzhou People's Republic of China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用一般科学;
  • 关键词

    biofabrication; micro tissue; controlled release; ceramic; tissue engineering;

    机译：生物制造;微组织;控释;陶瓷;组织工程;

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