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首页> 外文期刊>Bioelectromagnetics. >T‐Cell Differentiation to T Helper 9 Phenotype is Elevated by Extremely Low‐Frequency Electromagnetic Fields Via Induction of IL‐2 Signaling
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T‐Cell Differentiation to T Helper 9 Phenotype is Elevated by Extremely Low‐Frequency Electromagnetic Fields Via Induction of IL‐2 Signaling

机译：T细胞分化为T辅助辅助9表型通过极低频率的电磁场通过IL-2信号传导的极低频率电磁场升高

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摘要

Owing to the development of information technology and the electronics industry, and the increase in the use of electronic products, an increasing number of people are exposed to electromagnetic fields (EMFs) in daily life. There has been concern about the effects of EMFs on the human body. Th9 cells, which are characterized by the generation of interleukin‐(IL‐9), are a recently defined subset of T helper (Th) cells. In this study, we investigated the effect of extremely low‐frequency (60?Hz) EMFs, such as those generated by household power sources, at 0.8?mT intensity on CD4 + T cells. The exposure of CD4 + T cells to such EMFs under Th9‐polarizing conditions increased IL‐9 secretion and gene expression of transcription factors that are important for Th9 development. The expression of GATA3 increased in the early stage, and the phosphorylation of STAT5 and STAT6, which regulate the expression of GATA3, increased. In addition, EMFs increased the expression of IL‐2 by the T cells. In conclusion, the differentiation of CD4 + T cells to the Th9 phenotype was increased by exposure to extremely low‐frequency EMFs, and this appeared to be dependent on the IL‐2 signaling pathway. Furthermore, co‐cultures of EMF‐exposed Th9 cells and mast cells showed an increased expression of mast cell proteases, FcεR1α, and mast cell‐derived inflammatory cytokines compared with co‐cultures of non‐EMF‐exposed Th9 cells and mast cells. Our results suggest that EMFs enhance the differentiation of CD4 + T cells to the Th9 phenotype, resulting in mast cell activation and inflammation. Bioelectromagnetics. 2019;40:588–601. ? 2019 Bioelectromagnetics Society.
机译：由于信息技术和电子行业的发展，以及电子产品使用的增加，越来越多的人在日常生活中暴露于电磁场（EMF）。 EMFS对人体对人体的影响。 TH9细胞，其特征在于Inter zin-（IL-9），是最近定义了T辅助（Th）细胞的子集。在这项研究中，我们研究了极低频率（60次Hz）EMF的影响，例如家用电源产生的EMF，如CD4 + T细胞上的0.8μmt强度。 CD4 + T细胞在TH9-偏振条件下暴露于这种EMF，增加了IL-9分泌和转录因子的基因表达对于TH9发育很重要。早期的GATA3的表达增加，STAT5和Stat6的磷酸化，其调节GATA3的表达，增加。此外，EMFS通过T细胞增加IL-2的表达。总之，通过暴露于极低频率的EMF来增加CD4 + T细胞对TH9表型的分化，这似乎依赖于IL-2信号传导途径。此外，与非EMF暴露的TH9细胞和肥大细胞的共培养相比，EMF暴露的Th9细胞和肥大细胞和肥大细胞的共培养物表达了肥大细胞蛋白酶，FcεR1α和肥大细胞衍生的炎性细胞因子的表达。我们的研究结果表明，EMFS增强了CD4 + T细胞对TH9表型的分化，导致肥大细胞活化和炎症。生物电磁学。 2019; 40：588-601。还2019生物电磁学会。

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