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首页> 外文期刊>Biochemical Genetics >Haplogroup Structure and Genetic Variation Analyses of 60 Mitochondrial DNA Markers in Southern Shaanxi Han Population
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Haplogroup Structure and Genetic Variation Analyses of 60 Mitochondrial DNA Markers in Southern Shaanxi Han Population

机译：陕西南部60线粒体DNA标志物的HAPLOGroup结构和遗传变异分析

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摘要

Mitochondrial DNA (mtDNA) has been widely employed as one tool for the studies of human migration and phylogenetic evolution owing to the characteristics of its lack of recombination and matrilineal inheritance. In this study, we analyze genetic distributions of 60 mtDNA markers in 126 unrelated individuals of Southern Shaanxi Han population and classify their haplogroups. Genetic distribution comparisons between Southern Shaanxi Han and other populations from different continents are conducted based on the same mtDNA markers. The majority of 60 mtDNA markers are polymorphic in Southern Shaanxi Han population. The most common haplogroups observed in Southern Shaanxi Han population are B5, followed by D5, A, D4e, and N9a1 ' 3. Obtained matching probability for these 60 mtDNA markers indicates that the panel could be used as a valuable tool in forensic caseworks. Results of genetic distances (Fst) and multidimensional scaling analysis show that Southern Shaanxi Han population has relatively close genetic relationships with other Han populations in different regions. In conclusion, the panel comprising 60 mtDNA markers could be utilized for forensic applications in Southern Shaanxi Han population.
机译：由于其缺乏重组和母体遗传的特征，线粒体DNA（MTDNA）已被广泛用作人类迁移和系统发育进化的一种工具。在这项研究中，我们分析了陕西州南部南部126个无关个体的60例MTDNA标志物的遗传分布，并将其HAPLOGROUN分类。陕南汉族汉族与来自不同大洲的其他人群的遗传分布比较是基于同一MTDNA标志物进行的。大多数60例MTDNA标记是陕西州南部汉族人口的多态性。在陕南汉族人群中观察到的最常见的HAPLOG组是B5，其次是D5，A，D4E和N9A1'3.获得这些60 mTDNA标记的匹配概率表明，面板可以用作法医案例中的有价值的工具。遗传距离（FST）和多维缩放分析结果表明，陕南汉族人群与不同地区其他汉族人群的遗传关系相对较近。总之，包含60 mTDNA标记物的面板可用于陕南汉族南部的法医应用。

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