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首页> 外文期刊>Biochemical Genetics >Genetic variation of the peroxisome proliferator-activated receptor alpha gene (PPARA) in chickens bred for different purposes.
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Genetic variation of the peroxisome proliferator-activated receptor alpha gene (PPARA) in chickens bred for different purposes.

机译：不同目的的鸡中过氧化物激素激活受体α基因（PPARA）的遗传变异。

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摘要

Peroxisome proliferator-activated receptor alpha (PPARA) is involved in fatty acid oxidation by upregulating the expression of acyl-coenzyme A oxidase and carnitine palmitoyltransferase. In this study, PPARA gene variations in four chicken breeds (Guyuan, Wenchang, Tibetan, and Hisex) were detected by PCR-SSCP and DNA sequencing. The results indicated six genotypes (AA-EF). When compared with the PPARA reference sequence (GenBank accession no. AF163809), the nucleotide sequences of genotypes AA, BB, AB, and CC revealed silent mutations in the three Chinese breeds. The nucleotide sequences of genotypes DD and EF in Hisex showed several frame-shift mutations, implying variations involving five alleles of the PPARA gene in chicken breeds. In addition, the distribution of genotype frequency within the PPARA gene was significantly different in the four breeds studied, implying that this locus would probably be an effective marker in marker-assisted selection for layer, meat-and-egg, and broiler breeds.
机译：通过上调酰基 - 辅酶A氧化酶和肉毒氨基丙酰转移酶的表达，过氧化物体增殖剂活化受体α（PPARA）参与脂肪酸氧化。在本研究中，通过PCR-SSCP和DNA测序检测到四种鸡品种（Guantuan，Wenchang，Tibetan和Hisex）中的PPARA基因变化。结果表明了六种基因型（AA-EF）。与PPARA参考序列（GENBANK登录NO.AF163809）进行比较时，基因型AA，BB，AB和CC的核苷酸序列揭示了三种中药中的沉默突变。 Hisex中基因型DD和EF的核苷酸序列显示出几种帧间移位突变，暗示涉及养鸡品种PPARA基因的五个等位基因的变化。此外，在研究的四种品种中，PPARA基因内的基因型频率的分布显着差异，这意味着该基因座可能是标记辅助选择的有效标记，用于层，肉类和鸡蛋和肉鸡品种。

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