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首页> 外文期刊>Biochemical Genetics >Correlations of an Insertion/Deletion Polymorphism (rs10680577) in the RERT-lncRNA with the Susceptibility, Clinicopathological Features, and Prognosis of Lung Cancer
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Correlations of an Insertion/Deletion Polymorphism (rs10680577) in the RERT-lncRNA with the Susceptibility, Clinicopathological Features, and Prognosis of Lung Cancer

机译：在RERT-LNCRNA中的插入/缺失多态性（RS10680577）与肺癌的敏感性，临床病理特征和预后的相关性的相关性

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摘要

The aim of this study was to investigate the correlations of an Ins/Del polymorphism (rs10680577) in the RERT-lncRNA with the susceptibility, clinicopathological features, and prognosis of lung cancer. A total of 376 patients with lung cancer and 419 healthy subjects were enrolled in this study. The genotype of rs10680577 was performed using polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis. Quantitative real-time PCR was used to measure RERT-lncRNA and EGLN2 expressions. Subjects with Del allele of rs10680577 exhibited an elevated risk of lung cancer. The expressions of RERT-lncRNA and EGLN2 in tumor tissues were higher than adjacent normal tissues, manifesting a positive correlation. Compared to patientswith Ins/Ins genotype carriers, those with Ins/Del+Del/Del genotype carriers had upregulated expressions of RERT-lncRNA and EGLN2. Moreover, Ins/Del+Del/Del genotype and expressions of RERT-lncRNA and EGLN2 were associated with age, smoking habits, and TNM stage in lung cancer patients. Besides, patients with Ins/Ins genotype of rs10680577 had a longer OS than those with Ins/Del+Del/Del genotype carriers, and patients with lower expressions of RERT-lncRNA and EGLN2 presented a shorter OS than those with higher expressions. COX multivariate analysis demonstrated that Ins/Del+Del/Del genotype and higher expressions of RERT lncRNA and EGLN2 were risk factors affecting the prognosis of lung cancer. The Ins/Del polymorphism (rs10680577) in RERT-lncRNA was correlated with the risk, major clinicopathological features, and prognosis of lung cancer patients, and the patients with Ins/Del+Del/Del genotype carriers had higher expressions of RERT-lncRNA and EGLN2 than those with Ins/Ins carriers.
机译：本研究的目的是研究INS / DEL多态性（RS10680577）在RERT-LNCRNA中的相关性，肺癌的易感性，临床病理特征和预后。本研究共有376例肺癌和419名健康受试者的患者。使用聚合酶链反应（PCR）进行RS10680577的基因型，然后进行聚丙烯酰胺凝胶电泳。定量实时PCR用于测量RERT-LNCRNA和EGLN2表达。具有10680577的Del等位基因的受试者表现出肺癌的风险升高。肿瘤组织中RERT-LNCRNA和EGLN2的表达高于相邻的正常组织，表现为正相关。与患者的INS / INS基因型载体相比，具有INS / DEL + DEL / DEL基因型载体的那些具有上调的RERT-LNCRNA和EGLN2的表达。此外，INS / DEL + DEL / DEL基因型和RERT-LNCRNA和EGLN2的表达与肺癌患者的年龄，吸烟习惯和TNM阶段相关。此外，患有Rs10680577的INS​​ / INS基因型的患者的OS较长而不是INS / DEL + DEL / DEL基因型载体的核，并且RET-LNCRNA和EGLN2表达较低的患者呈现比具有更高表达更高的OS较短的OS。 Cox多变量分析证明INS / DEL + DEL / DEL基因型和RERT LNCRNA和EGLN2的更高表达是影响肺癌预后的危险因素。 RERT-LNCRNA中的INS / DEL多态性（RS10680577）与肺癌患者的风险，主要临床病理特征和预后相关，并且INS / DEL + DEL / DEL基因型携带者的患者具有更高的RERT-LNCRNA表达EGLN2比INS / INS载体的2。

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  • 来源
    《Biochemical Genetics》 |2019年第1期|共12页
  • 作者

    Zhu Jing; Luo Jin-Zhu; Li Cheng-Bin;

  • 作者单位

    Yangtze Univ Clin Med Coll 2 Jingzhou Cent Hosp Dept Lab Med Jingzhou 434020 Hubei Peoples R;

    Yangtze Univ Clin Med Coll 2 Jingzhou Cent Hosp Dept Lab Med Jingzhou 434020 Hubei Peoples R;

    Yangtze Univ Clin Med Coll 2 Jingzhou Cent Hosp Dept Lab Med Jingzhou 434020 Hubei Peoples R;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    Lung cancer; RERT-lncRNA; rs10680577; EGLN2;

    机译：肺癌;rert-lncrna;rs10680577;egln2;

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