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首页> 外文期刊>Biochemical Genetics >Adaptive evolution and frequent gene conversion in the brain expressed X-linked gene family in mammals.
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Adaptive evolution and frequent gene conversion in the brain expressed X-linked gene family in mammals.

机译：脑中脑中脑中的自适应演化和频繁基因转化表达哺乳动物中的X型基因家族。

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摘要

This work examines the molecular evolution of a brain-expressed X-linked gene family in the mammalian genomes of human, chimp, macaque, mouse, rat, dog, and cow. The gene structures are well conserved across family members and among the mammals in that all five members have three exons with the first two exons untranslated. Furthermore, the five members are arranged tandemly on chromosome X with Bex5, Bex1, Bex2 on the negative strand and Bex4, Bex3 on the positive strand, and this physical arrangement remains conserved among species. Sequence analyses indicate that gene conversion has been frequent and ongoing among Bex1-4, occurring in multiple species independently. All gene conversions in different species between Bex1 and Bex4, and between Bex2 and Bex3, appear to be limited to the upstream regions of the third exon, whereas the gene conversions occurred independently in different species between Bex1 and Bex2 and cover only the third exon. Bex5 appears to have little exchange of genetic information with other members, possibly due to its distance from other members. The GC content decreases from 5'-UTR, intron 1, intron 2, coding region, to 3'-UTR, reflecting faithfully the frequency of gene conversion in different regions of the Bex genes. Sequence analyses also suggest that both relaxed selective constraint and positive selection have acted on the Bex members after duplication. In particular, Bex3 shows strong evidence of positive selection and seems to have evolved a new gene function after gene duplication.
机译：这项工作研究了人，黑猩猩，短尾猿，小鼠，大鼠，狗和牛的哺乳动物基因组中脑表达的X型基因家族的分子演变。基因结构在家庭成员和哺乳动物中都很好地保守，因为所有五个成员都有三个外显子，前两个外显子未翻译。此外，五个成员在染色体X上缠绕在染色体X上，在负股线上的BEX5，BEX1，BEX2，BEX4，正股上的BEX3，并且这种物理安排在物种之间保持守恒。序列分析表明基因转化频繁且在BEX1-4中常常持续，独立于多种物种。 Bex1和Bex4之间的不同物种的所有基因转换，Bex2和Bex3之间的所有基因转化似乎限于第三外显子的上游区域，而基因转化在Bex1和Bex2之间的不同物种中独立发生，并且仅覆盖第三个外显子。 Bex5似乎与其他成员交换了遗传信息，可能是由于其与其他成员的距离。 GC含量从5'-UTR，内含子1，内含子2，编码区减少到3'-UTR，忠实地反映了BEX基因的不同区域中基因转化的频率。序列分析还表明，在重复后，宽松的选择性约束和阳性选择都在Bex成员上作用。特别是，BEX3显示出阳性选择的强烈证据，似乎在基因重复后发育了新的基因功能。

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  • 来源
    《Biochemical Genetics》 |2008年第6期|共19页
  • 作者

    Zhang L;

  • 作者单位

    Department of Computer Science Virginia Tech 2050 Torgersen Hall Blacksburg VA 24061-0106 USA.;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
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