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首页> 外文期刊>Biochemical Genetics >Bioinformatics analysis of lactoferrin gene for several species.
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Bioinformatics analysis of lactoferrin gene for several species.

机译：几种物种乳铁蛋白基因的生物信息学分析。

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摘要

Much attention has been focused on the study of lactoferrin due to its function in antibacterial, antiviral, antifungal, anti-inflammatory, anti-oxidant, and immunomodulatory activities. A total of 60 lactoferrin (LF) gene sequences with the complete coding regions (CDS) and corresponding amino acids belonging to 11 species were analyzed, and the differentiation within and among the species was also studied. The results showed that most of the species have the stop codon TAA, with the variation of TGA for Mus musculus. The length of the LF gene with the complete CDS varies greatly, from 2,055 to 2,190 bp, due to deletion, insertion, and stop codon mutation resulting in elongation. Observed genetic diversity was higher among species than within species, and Sus scrofa had more polymorphisms than any other species. Novel amino acid variation sites were detected within several species (8 in Homo sapiens, 6 in Mus musculus, 6 in Capra hircus, 10 in Bos taurus, and 20 in Sus scrofa), which might be used to illustrate the functional variation. Differentiation of the LF gene was obvious among species, and the clustering result was consistent with the taxonomy in the National Center for Biotechnology Information.
机译：由于其在抗菌，抗病毒，抗真菌，抗炎，抗氧化，抗氧化剂和免疫调节活性的功能上，很多关注已经专注于乳铁蛋白的研究。分析了具有完整编码区（CD）和属于11种物种的相应氨基酸的60乳铁蛋白（LF）基因序列，还研究了物种内部和中间的分化。结果表明，大多数物种具有止芯沉积柱TAA，具有TGA的TGA为亩肌肉。由于缺失，插入和停止密码子突变导致伸长率，LF基因的LF基因的长度从2,055到2,190bp变化。在物种之内观察到的遗传多样性比物种在物种内更高，并且SUS Scrofa具有比任何其他物种更多的多态性。在几种物种（Homo Sapiens中的8个中，在Mus Musculus 6中的6个中，在Capra Hircus，10中的6位，博斯特鲁斯10中，在SUS Scrofa中的20个中，可能用于说明功能变异。 LF基因的分化在物种中显而易见，聚类结果与国家生物技术信息中心的分类符合。

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