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首页> 外文期刊>Biochemical Genetics >Association of Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR gamma 2) Gene with Type 2 Diabetes Mellitus in Ethnic Kashmiri Population
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Association of Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR gamma 2) Gene with Type 2 Diabetes Mellitus in Ethnic Kashmiri Population

机译：过氧化物体增殖物激活的受体γ（PPARγ2）基因的Pro12Ala多态性与2型糖尿病群岛胰腺炎患者

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摘要

Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia associated with insulin resistance and relative insulin deficiency. T2DM is believed to be attributable to the combined effect of genetic and environmental factors. Peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) is one of the main candidate genes that are implicated in T2DM. A common proline 12 alanine (Pro12Ala) polymorphism in PPAR gamma 2 has been shown to be associated with T2DM. The aim of this work was to investigate the possible role of PPAR gamma 2 gene polymorphism, as a genetic risk factor for T2DM. The study comprised 200 ethnic unrelated subjects (100 T2DM patients and 100 controls). PCR-RFLP technique was used for genotyping analysis. The frequency of the Pro allele was 79 and 91.5 % for controls and cases, respectively (P < 0.05; OR 3.2; 95 % CI 1.64-6.3). The Pro12Ala polymorphism was in Hardy-Weinberg equilibrium in both patients and controls (chi(2) = 0.13, P > 0.05). We found a significant association of Pro12Ala polymorphism of PPAR gamma 2 gene with T2DM, however the genotypes showed statistically significant association only with few clinical parameters including body mass index, total cholesterol, and low-density lipoprotein (P 0.05). The study signifies that Pro allele in PPAR gamma 2 may be a genotypic risk factor that confers susceptibility to T2DM in ethnic Kashmiri population.
机译：2型糖尿病（T2DM）的特征在于与胰岛素抗性相关的慢性高血糖和相对胰岛素缺乏。 T2DM被认为是遗传和环境因素的综合影响。过氧化物体增殖物激活的受体γ2（PPARγ2）是含有T2DM的主要候选基因之一。 PPARγ2中的常见脯氨酸12丙氨酸（Pro12Ala）多态性已显示与T2DM相关。这项工作的目的是探讨PPARγ2基因多态性的可能作用，作为T2DM的遗传危险因素。该研究包括200个族裔无关受试者（100吨T2DM患者和100名对照）。 PCR-RFLP技术用于基因分型分析。对于对照和病例，Pro等位基因的频率分别为79和91.5％（P <0.05;或3.2; 95％CI 1.64-6.3）。 Pro12Ala多态性在患者和对照（CHI（2）= 0.13，P> 0.05）中，在Hardy-Weinberg平衡中。我们发现PPARγ2基因的Pro12Ala多态性与T2DM的重大关联，但基因型仅显示统计学意义的关联，只有少数临床参数，包括体重指数，总胆固醇和低密度脂蛋白（P 0.05）。该研究表明PPARγ2中的Pro等位基因可能是基因型危险因素，可赋予T2DM在克什米尔人群中的易感性。

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