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首页> 外文期刊>Biochemistry >The Role of Liquid-Liquid Phase Separation in the Compartmentalization of Cell Nucleus and Spatial Genome Organization
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The Role of Liquid-Liquid Phase Separation in the Compartmentalization of Cell Nucleus and Spatial Genome Organization

机译:液液相分离在细胞核和空间基因组组织的分区化中的作用

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摘要

Functional compartmentalization of the cell nucleus plays an important role in the regulation of genome activity by providing accumulation of enzymes and auxiliary factors in the reaction centers, such as transcription factories, Cajal bodies, speckles, etc. The mechanisms behind the nucleus functional compartmentalization are still poorly understood. There are reasons to believe that the key role in the nucleus compartmentalization belongs to the process of liquid-liquid phase separation. In this brief review, we analyze results of experimental studies demonstrating that liquid-liquid phase separation not only governs functional compartmentalization of the cell nucleus but also contributes to the formation of the 3D genomic architecture.
机译:细胞核的功能闭合剂化在通过提供反应中心中的酶和辅助因子的积累,例如转录工厂,CAJAL体,斑点等,在基因组活动调节中起重要作用。核心功能分区化后面的机制仍然存在 理解得很差。 有理由认为,核隔层中的关键作用属于液 - 液相分离的方法。 在这篇简短的综述中,我们分析了实验研究的结果,证明液 - 液相分离不仅治理细胞核的功能性分区,而且有助于形成3D基因组结构。

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